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CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands | 3 Months Ended
--- | ---
Mar. 31, 2025 | Mar. 31, 2024
Cash flows from operating activities: |  |
Net (loss) income | $ (42,451) | $ 86,139
Adjustments to reconcile net (loss) income to net cash provided by operating activities: |  |
Change in estimated fair value of contingent liabilities | 1,879 | (33)
Depreciation of fixed assets and amortization of intangible assets | 8,770 | 8,765
Amortization/accretion of premium (discount) on investments, net | (839) | (157)
Amortization of debt discount and issuance fees | 136 | 84
Non-cash income from financial royalty assets | (461) | 0
CECL adjustment to financial royalty assets | (330) | (2,841)
Loss (gain) on derivative instruments | 174 | (196)
Losses from equity method investment in Primrose Bio | 0 | 2,352
Share-based compensation | 7,836 | 7,334
Deferred income taxes, net | (8,844) | 19,546
Gain from short-term investments | 12,367 | (110,772)
Lease amortization expense | 571 | 478
Other | 915 | (210)
Changes in operating assets and liabilities, net of acquisitions: |  |
Accounts receivable | (576) | 3,462
Inventory | (500) | 2,632
Accounts payable and accrued liabilities | (2,149) | (1,382)
Income tax receivable and payable | 335 | 7,533
Deferred revenue | (293) | (540)
Other assets and liabilities | (1,985) | (3,462)
Net cash (used in) provided by operating activities | (25,445) | 18,732
Cash flows from investing activities: |  |
Acquisition of financial royalty assets | (1,821) | (2,443)
Proceeds from financial royalty assets | 3,149 | 1,942
Purchases of property and equipment | (214) | (105)
Purchases of short-term investments | (59,374) | (77,634)
Proceeds from sale of short-term investments | 38,414 | 60,919
Proceeds from maturity of short-term investments | 32,360 | 14,544
Cash paid for investment in Primrose Bio | 0 | (998)
Purchases of derivatives | (7,620) | 0
Net cash provided by (used in) investing activities | 4,894 | (3,775)
Cash flows from financing activities: |  |
Payments under finance lease obligations | (7) | (5)
Net proceeds from stock option exercises and ESPP | 4,222 | 15,304
Taxes paid related to net share settlement of equity awards | (8,891) | (3,076)
Cash paid for debt issuance costs | (71) | (41)
Net cash (used in) provided by financing activities | (4,747) | 12,182
Effect of exchange rate changes on cash and cash equivalents | 1,058 | 0
Net (decrease) increase in cash and cash equivalents, including cash and cash equivalents classified within assets held for sale | (24,240) | 27,139
Less: net increase in cash and cash equivalents classified within assets held for sale | (78) | 0
Net (decrease) increase in cash and cash equivalents | (24,318) | 27,139
Cash and cash equivalents at beginning of period | 72,307 | 22,954
Cash and cash equivalents at end of period | 47,989 | 50,093
Supplemental disclosure of cash flow information: |  |
Interest paid | 97 | 59
Taxes paid | 280 | 0
Supplemental schedule of non-cash investing and financing activities: |  |
Addition of right-of-use assets and lease liabilities | 828 | 0
Accrued purchases of financial royalty assets | 0 | 2,129
Accrued fixed asset purchases | 0 | 2
Unrealized gain (loss) on available-for-sale investments, net of tax | $ (22) | $ (93)

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