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CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands | 6 Months Ended
--- | ---
Jun. 30, 2025 | Jun. 30, 2024
Cash flows from operating activities: |  |
Net (loss) income | $ (37,604) | $ 34,228
Adjustments to reconcile net (loss) income to net cash (used in) provided by operating activities: |  |
Change in estimated fair value of contingent liabilities | 1,931 | 1,200
Depreciation of fixed assets and amortization of intangible assets | 17,292 | 17,618
Accretion of short-term investments | (1,605) | (587)
Amortization of debt discount and issuance fees | 261 | 180
Non-cash income from financial royalty assets | (888) | 0
CECL adjustment to financial royalty assets | (750) | (4,260)
Impairment loss of financial royalty assets | 0 | 26,491
Loss (gain) on derivative instruments | 245 | (1,696)
Losses from equity method investment in Primrose Bio | 0 | 10,382
Fair value adjustment to Primrose Bio securities investments | 0 | 25,759
Share-based compensation | 17,833 | 18,394
Deferred income taxes, net | (9,169) | (1,120)
Loss (gain) from short-term investments | 11,428 | (96,516)
Lease amortization expense | 983 | 982
Other | 1,736 | 358
Changes in operating assets and liabilities: |  |
Accounts receivable | (3,341) | (5,587)
Inventory | (1,375) | 5,121
Accounts payable and accrued liabilities | (2,556) | 390
Income tax receivable and payable | 2,758 | 8,486
Deferred revenue | (578) | (940)
Other assets and liabilities | (6,247) | (6,837)
Net cash (used in) provided by operating activities | (9,646) | 32,046
Cash flows from investing activities: |  |
Acquisition of financial royalty assets | (1,821) | (4,174)
Proceeds from financial royalty assets | 5,179 | 4,207
Purchases of property and equipment | (428) | (513)
Purchases of short-term investments | (122,717) | (102,075)
Proceeds from sale of short-term investments | 38,414 | 98,908
Proceeds from maturity of short-term investments | 83,220 | 23,611
Cash paid for investment in Primrose Bio | 0 | (998)
Cash paid for Palvella notes receivable | 0 | (2,500)
Cash paid for the Agenus transaction | 0 | (75,000)
Purchase of Castle Creek derivatives | (7,620) | 0
Net cash used in investing activities | (5,773) | (58,534)
Cash flows from financing activities: |  |
Payments under finance lease obligations | (14) | (9)
Net proceeds from stock option exercises and ESPP | 12,461 | 24,856
Taxes paid related to net share settlement of equity awards | (9,036) | (3,076)
Cash paid for debt issuance costs | (73) | (98)
Proceeds from Pelthos investors | 6,910 | 0
Net cash provided by financing activities | 10,248 | 21,673
Effect of exchange rate changes on cash and cash equivalents | 3,350 | 0
Net decrease in cash and cash equivalents, including cash and cash equivalents classified within assets held for sale | (1,821) | (4,815)
Less: net increase in cash and cash equivalents classified within assets held for sale | (2,817) | 0
Net decrease in cash and cash equivalents | (4,638) | (4,815)
Cash and cash equivalents at beginning of period | 72,307 | 22,954
Cash and cash equivalents at end of period | 67,669 | 18,139
Supplemental disclosure of cash flow information: |  |
Interest paid | 201 | 112
Taxes paid | 4,554 | 5,772
Supplemental schedule of non-cash investing and financing activities: |  |
Addition of right-of-use assets and lease liabilities | 2,315 | 1,737
Accrued fixed asset purchases | 9 | 25
Unrealized loss on available-for-sale investments, net of tax | $ (71) | $ (118)

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