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Fair Value Measurements (Tables)
 6 Months Ended
Jun. 30, 2025
Fair Value Disclosures [Abstract]  
Schedule of Assets and Liabilities Measured at Fair Value
The following table presents the hierarchy for our assets and liabilities measured at fair value (in thousands):
June 30, 2025December 31, 2024
Level 1Level 2Level 3TotalLevel 1Level 2Level 3Total
Assets:
Short-term investments, excluding Viking(1)
$72,560 $78,291 $— $150,851 $81,807 $61,811 $— $143,618 
Investment in Viking common stock26,500 — — 26,500 40,240 — — 40,240 
Derivative assets(2)
— — 17,958 17,958 — — 10,583 10,583 
     Total assets$99,060 $78,291 $17,958 $195,309 $122,047 $61,811 $10,583 $194,441 
Liabilities:
Contingent liabilities - CyDex$— $— $351 $351 $— $— $383 $383 
Contingent liabilities - Metabasis(3)
— 5,211 — 5,211 — 3,298 — 3,298 
     Total liabilities$— $5,211 $351 $5,562 $— $3,298 $383 $3,681 
(1) Excluding our investment in Viking common stock, corporate equity securities, and US government securities, our short-term investments in marketable debt and equity securities are classified as available-for-sale securities based on management’s intentions and are at level 2 of the fair value hierarchy, as these investment securities are valued based upon quoted prices for identical or similar instruments in markets that are not active, and model-based valuation techniques for which all significant assumptions are observable in the market. We have classified marketable securities with original maturities of greater than one year as short-term investments based upon our ability and intent to use any or all of those marketable securities to satisfy the liquidity needs of our current operations.
(2) Derivative assets include instruments used for risk-management purposes, and other instruments. Derivative assets which are not used for risk management purposes include: (a) Agenus Partnered Programs, (b) Primrose mRNA derivative, (c) Castle Creek Milestone, (d) Agenus Warrant, and (e) Castle Creek Warrant. They are recognized as derivative assets under ASC 815, Derivatives and Hedging. The fair value of the Agenus Partnered Programs, Primrose mRNA, and Castle Creek Milestone derivative assets was determined using a discounted cash flow approach, utilizing the mostly-likely cash flows which considered the probability of success for the underlying clinical programs. The discount rate used contemplates the underlying credit and business risk of the partnered programs. At June 30, 2025, the discount rates used a range between 15% and 28%. At December 31, 2024, the discount rate used a range between 15% and 28%. The fair value of the Agenus Warrant and Castle Creek Warrant was determined using a Black-Scholes model.
(3) In connection with our acquisition of Metabasis in January 2010, we issued Metabasis stockholders four tradable CVRs, one CVR from each of four respective series of CVR, for each Metabasis share. The CVRs entitle Metabasis stockholders to cash payments as frequently as every six months as cash is received by us from proceeds from the sale or partnering of any of the Metabasis drug development programs, among other triggering events. The liability for the CVRs is determined using quoted prices in a market that is not active for the underlying CVR. The carrying amount of the liability may fluctuate significantly based upon quoted market prices and actual amounts paid under the agreements may be materially different than the carrying amount of the liability. Several of the Metabasis drug development programs have been outlicensed to Viking, including VK2809. VK2809 is a novel selective TR-β agonist with potential in multiple indications, including hypercholesterolemia, dyslipidemia, NASH, and X-ALD. Under the terms of the agreement with Viking, we may be entitled to up to $375 million of development, regulatory and commercial milestones and tiered royalties on potential future sales including a $10 million payment upon initiation of a Phase 3 clinical trial. During the three months ended June 30, 2025 and 2024, we recorded a change in the fair value of the Metabasis CVR liability that amounted to $0.1 million and $1.1 million, respectively, to mark to market. During the six months ended June 30, 2025 and 2024, we recorded a change in the fair value of the Metabasis CVR liability that amounted to $1.9 million and $1.1 million, respectively, to mark to market.
Schedule of Reconciliation of Level 3 Financial Instruments
A reconciliation of the level 3 financial instruments as of June 30, 2025 is as follows (in thousands):
Assets
Fair value of level 3 financial instruments as of December 31, 2024
$10,583 
Additions to derivative assets7,620 
Fair value adjustments to derivative assets(245)
Fair value of level 3 financial instruments as of June 30, 2025
$17,958 
Liabilities
Fair value of level 3 financial instruments as of December 31, 2024
$383 
Payments to CVR holders and other contingent payments(50)
Fair value adjustments to contingent liabilities18 
Fair value of level 3 financial instruments as of June 30, 2025
$351