<SEC-DOCUMENT>0000899243-21-046968.txt : 20211206
<SEC-HEADER>0000899243-21-046968.hdr.sgml : 20211206
<ACCEPTANCE-DATETIME>20211206171105
ACCESSION NUMBER:		0000899243-21-046968
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20211202
FILED AS OF DATE:		20211206
DATE AS OF CHANGE:		20211206

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Medicxi Growth I LP
		CENTRAL INDEX KEY:			0001690310
		STATE OF INCORPORATION:			Y9

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-40445
		FILM NUMBER:		211473851

	BUSINESS ADDRESS:	
		STREET 1:		C/O ELIAN FUND SERVICES (JERSEY) LIMITED
		STREET 2:		44 ESPLANADE
		CITY:			ST HELIER
		STATE:			Y9
		ZIP:			JE4 9WG
		BUSINESS PHONE:		44 (0)1534 504343

	MAIL ADDRESS:	
		STREET 1:		C/O ELIAN FUND SERVICES (JERSEY) LIMITED
		STREET 2:		44 ESPLANADE
		CITY:			ST HELIER
		STATE:			Y9
		ZIP:			JE4 9WG

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Medicxi Growth Co-Invest I LP
		CENTRAL INDEX KEY:			0001715578

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-40445
		FILM NUMBER:		211473850

	BUSINESS ADDRESS:	
		STREET 1:		C/O INTERTRUST FUND SERVICES (JERSEY)
		STREET 2:		44 ESPLANADE
		CITY:			ST. HELIER
		STATE:			Y9
		ZIP:			JE4 9WG
		BUSINESS PHONE:		44 (0) 1534 504343

	MAIL ADDRESS:	
		STREET 1:		C/O INTERTRUST FUND SERVICES (JERSEY)
		STREET 2:		44 ESPLANADE
		CITY:			ST. HELIER
		STATE:			Y9
		ZIP:			JE4 9WG

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Medicxi Ventures Management (Jersey) Ltd
		CENTRAL INDEX KEY:			0001715579
		STATE OF INCORPORATION:			Y9

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-40445
		FILM NUMBER:		211473852

	BUSINESS ADDRESS:	
		STREET 1:		C/O INTERTRUST FUND SERVICES (JERSEY)
		STREET 2:		44 ESPLANADE
		CITY:			ST. HELIER
		STATE:			Y9
		ZIP:			JE4 9WG
		BUSINESS PHONE:		44 (0) 1534 504343

	MAIL ADDRESS:	
		STREET 1:		C/O INTERTRUST FUND SERVICES (JERSEY)
		STREET 2:		44 ESPLANADE
		CITY:			ST. HELIER
		STATE:			Y9
		ZIP:			JE4 9WG

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Medicxi Growth I GP Ltd
		CENTRAL INDEX KEY:			0001715600

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-40445
		FILM NUMBER:		211473849

	BUSINESS ADDRESS:	
		STREET 1:		C/O INTERTRUST FUND SERVICES (JERSEY)
		STREET 2:		44 ESPLANADE
		CITY:			ST. HELIER
		STATE:			Y9
		ZIP:			JE4 9WG
		BUSINESS PHONE:		44 (0) 1534 504343

	MAIL ADDRESS:	
		STREET 1:		C/O INTERTRUST FUND SERVICES (JERSEY)
		STREET 2:		44 ESPLANADE
		CITY:			ST. HELIER
		STATE:			Y9
		ZIP:			JE4 9WG

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Centessa Pharmaceuticals plc
		CENTRAL INDEX KEY:			0001847903
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			X0
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		3RD FLOOR
		STREET 2:		1 ASHLEY ROAD
		CITY:			ALTRINCHAM, CHESHIRE
		STATE:			X0
		ZIP:			WA14 2DT
		BUSINESS PHONE:		44 7391 789784

	MAIL ADDRESS:	
		STREET 1:		3RD FLOOR
		STREET 2:		1 ASHLEY ROAD
		CITY:			ALTRINCHAM, CHESHIRE
		STATE:			X0
		ZIP:			WA14 2DT

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	Centessa Pharmaceuticals Ltd
		DATE OF NAME CHANGE:	20210224
</SEC-HEADER>
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<TYPE>4
<SEQUENCE>1
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<DESCRIPTION>FORM 4 SUBMISSION
<TEXT>
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    <documentType>4</documentType>

    <periodOfReport>2021-12-02</periodOfReport>

    <notSubjectToSection16>0</notSubjectToSection16>

    <issuer>
        <issuerCik>0001847903</issuerCik>
        <issuerName>Centessa Pharmaceuticals plc</issuerName>
        <issuerTradingSymbol>CNTA</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001715579</rptOwnerCik>
            <rptOwnerName>Medicxi Ventures Management (Jersey) Ltd</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O INTERTRUST FUND SERVICES (JERSEY)</rptOwnerStreet1>
            <rptOwnerStreet2>LIMITED 44 ESPLANADE</rptOwnerStreet2>
            <rptOwnerCity>ST. HELIER</rptOwnerCity>
            <rptOwnerState>Y9</rptOwnerState>
            <rptOwnerZipCode>JE4 9WG</rptOwnerZipCode>
            <rptOwnerStateDescription>JERSEY</rptOwnerStateDescription>
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            <isOther>0</isOther>
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    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001690310</rptOwnerCik>
            <rptOwnerName>Medicxi Growth I LP</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O INTERTRUST FUND SERVICES (JERSEY)</rptOwnerStreet1>
            <rptOwnerStreet2>LIMITED 44 ESPLANADE</rptOwnerStreet2>
            <rptOwnerCity>ST. HELIER</rptOwnerCity>
            <rptOwnerState>Y9</rptOwnerState>
            <rptOwnerZipCode>JE4 9WG</rptOwnerZipCode>
            <rptOwnerStateDescription>JERSEY</rptOwnerStateDescription>
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    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001715578</rptOwnerCik>
            <rptOwnerName>Medicxi Growth Co-Invest I LP</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O INTERTRUST FUND SERVICES (JERSEY)</rptOwnerStreet1>
            <rptOwnerStreet2>LIMITED 44 ESPLANADE</rptOwnerStreet2>
            <rptOwnerCity>ST. HELIER</rptOwnerCity>
            <rptOwnerState>Y9</rptOwnerState>
            <rptOwnerZipCode>JE4 9WG</rptOwnerZipCode>
            <rptOwnerStateDescription>JERSEY</rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
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    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001715600</rptOwnerCik>
            <rptOwnerName>Medicxi Growth I GP Ltd</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O INTERTRUST FUND SERVICES (JERSEY)</rptOwnerStreet1>
            <rptOwnerStreet2>LIMITED 44 ESPLANADE</rptOwnerStreet2>
            <rptOwnerCity>ST. HELIER</rptOwnerCity>
            <rptOwnerState>Y9</rptOwnerState>
            <rptOwnerZipCode>JE4 9WG</rptOwnerZipCode>
            <rptOwnerStateDescription>JERSEY</rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Ordinary Shares</value>
                <footnoteId id="F1"/>
            </securityTitle>
            <transactionDate>
                <value>2021-12-02</value>
            </transactionDate>
            <deemedExecutionDate></deemedExecutionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>P</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionTimeliness>
                <value></value>
            </transactionTimeliness>
            <transactionAmounts>
                <transactionShares>
                    <value>33530</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>12.82</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>3936970</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See footnote</value>
                    <footnoteId id="F2"/>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Ordinary Shares</value>
                <footnoteId id="F1"/>
            </securityTitle>
            <transactionDate>
                <value>2021-12-02</value>
            </transactionDate>
            <deemedExecutionDate></deemedExecutionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>P</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionTimeliness>
                <value></value>
            </transactionTimeliness>
            <transactionAmounts>
                <transactionShares>
                    <value>796</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>12.82</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>93526</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See footnote</value>
                    <footnoteId id="F3"/>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Ordinary Shares</value>
                <footnoteId id="F1"/>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>4398519</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See footnote</value>
                    <footnoteId id="F4"/>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Ordinary Shares</value>
                <footnoteId id="F1"/>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>55677</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See footnote</value>
                    <footnoteId id="F5"/>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Ordinary Shares</value>
                <footnoteId id="F1"/>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>9403092</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See footnote</value>
                    <footnoteId id="F6"/>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Ordinary Shares</value>
                <footnoteId id="F1"/>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>236108</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See footnote</value>
                    <footnoteId id="F7"/>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
    </nonDerivativeTable>

    <footnotes>
        <footnote id="F1">The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share.</footnote>
        <footnote id="F2">Held by Medicxi Growth I LP, a Jersey limited partnership (&quot;Medicxi Growth I&quot;). Medicxi Growth I GP Limited, a Jersey limited liability company (&quot;MGI GP&quot;), is the sole managing general partner of Medicxi Growth I, and Medicxi Ventures Management (Jersey) Limited, a Jersey limited liability company (&quot;Medicxi Manager&quot;) is the sole manager of Medicxi Growth I.  The Reporting Persons disclaim Section 16 beneficial ownership of the securities held by Medicxi Growth I, except to the extent of their respective pecuniary interest therein, if any, and this report shall not be deemed to be an admission that they have beneficial ownership of such shares for Section 16 or any other purpose.</footnote>
        <footnote id="F3">Held by Medicxi Growth Co-Invest I LP, a Jersey limited partnership (&quot;Medicxi Growth Co-Invest I&quot;).  MGI GP is the sole managing general partner of Medicxi Growth Co-Invest I, and Medicxi Manager is the sole manager of Medicxi Growth Co-Invest I.  The Reporting Persons disclaim Section 16 beneficial ownership of the securities held by Medicxi Growth Co-Invest I, except to the extent of their respective pecuniary interest therein, if any, and this report shall not be deemed to be an admission that they have beneficial ownership of such shares for Section 16 or any other purpose.</footnote>
        <footnote id="F4">Held by Medicxi Ventures I LP, a Jersey limited partnership (&quot;Medicxi Ventures I&quot;). Medicxi Ventures I GP Limited, a Jersey limited liability company (&quot;MVI GP&quot;), is the sole managing general partner of Medicxi Ventures I, and Medicxi Manager is the sole manager of Medicxi Ventures I.  The Reporting Persons disclaim Section 16 beneficial ownership of the securities held by Medicxi Ventures I, except to the extent of their respective pecuniary interest therein, if any, and this report shall not be deemed to be an admission that they have beneficial ownership of such shares for Section 16 or any other purpose.</footnote>
        <footnote id="F5">Held by Medicxi Co-Invest I LP, a Jersey limited partnership (&quot;Medicxi Co-Invest I&quot;). MVI GP is the sole managing general partner of Medicxi Co-Invest I, and Medicxi Manager is the sole manager of Medicxi Co-Invest I.  The Reporting Persons disclaim Section 16 beneficial ownership of the securities held by Medicxi Co-Invest I, except to the extent of their respective pecuniary interest therein, if any, and this report shall not be deemed to be an admission that they have beneficial ownership of such shares for Section 16 or any other purpose.</footnote>
        <footnote id="F6">Held by Medicxi Secondary I LP, a Jersey limited partnership (&quot;Medicxi Secondary I&quot;).  Medicxi Secondary I GP Limited, a Jersey limited liability company (&quot;MSI GP&quot;), is the sole managing general partner of Medicxi Secondary I, and Medicxi Manager is the sole manager of Medicxi Secondary I.  The Reporting Persons disclaim Section 16 beneficial ownership of the securities held by Medicxi Secondary I, except to the extent of their respective pecuniary interest therein, if any, and this report shall not be deemed to be an admission that they have beneficial ownership of such shares for Section 16 or any other purpose.</footnote>
        <footnote id="F7">Held by Medicxi Secondary Co-Invest I LP, a Jersey limited partnership (&quot;Medicxi Secondary Co-Invest I&quot;).  MSI GP is the sole managing general partner of Medicxi Secondary Co-Invest I, and Medicxi Manager is the sole manager of Medicxi Secondary Co-Invest I.  The Reporting Persons disclaim Section 16 beneficial ownership of the securities held by Medicxi Secondary Co-Invest I, except to the extent of their respective pecuniary interest therein, if any, and this report shall not be deemed to be an admission that they have beneficial ownership of such shares for Section 16 or any other purpose.</footnote>
    </footnotes>

    <remarks>Medicxi Ventures (UK) LLP and Medicxi Ventures (Jersey) Limited act as sub-advisers to Index Ventures Life VI (Jersey) Limited, which acts as the adviser to Index Ventures Life VI (Jersey) LP, and as such, Index Ventures Life VI and Yucca (Jersey) SLP, each of which hold Ordinary Shares as of the date hereof, and the Medicxi Funds may be deemed to be members of a &quot;group&quot; as defined in Rule 13d-5 of the Securities Exchange Act of 1934, as amended.</remarks>

    <ownerSignature>
        <signatureName>Medicxi Ventures Management (Jersey) Limited, By: /s/ Francois Chesnay, Its: Director</signatureName>
        <signatureDate>2021-12-06</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>Medicxi Growth I LP, By: Medicxi Ventures Management (Jersey) Limited, By: /s/ Francois Chesnay, Its: Director</signatureName>
        <signatureDate>2021-12-06</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>Medicxi Growth Co-Invest I LP, By: Medicxi Ventures Management (Jersey) Limited, By: /s/ Francois Chesnay, Its: Director</signatureName>
        <signatureDate>2021-12-06</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>Medicxi Growth I GP Limited, By: /s/ Francois Chesnay, Its: Director</signatureName>
        <signatureDate>2021-12-06</signatureDate>
    </ownerSignature>
</ownershipDocument>
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</SEC-DOCUMENT>
