    <SEC-DOCUMENT>0001999371-25-005478-index.html : 20250506
    <SEC-HEADER>0001999371-25-005478.hdr.sgml : 20250506
    <ACCEPTANCE-DATETIME>20250506090014
    ACCESSION NUMBER:		0001999371-25-005478
    CONFORMED SUBMISSION TYPE:	DEF 14A
    PUBLIC DOCUMENT COUNT:		7
    CONFORMED PERIOD OF REPORT:	20250620
    FILED AS OF DATE:		20250506
    DATE AS OF CHANGE:		20250506

    FILER:

    	COMPANY DATA:
    		COMPANY CONFORMED NAME:			Centessa Pharmaceuticals plc
    		CENTRAL INDEX KEY:			0001847903
    		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
    		ORGANIZATION NAME:           	03 Life Sciences
    		EIN:				000000000
    		STATE OF INCORPORATION:			X0
    		FISCAL YEAR END:			1231

    	FILING VALUES:
    		FORM TYPE:		DEF 14A
    		SEC ACT:		1934 Act
    		SEC FILE NUMBER:	001-40445
    		FILM NUMBER:		25915570

    	BUSINESS ADDRESS:
    		STREET 1:		3RD FLOOR
    		STREET 2:		1 ASHLEY ROAD
    		CITY:			ALTRINCHAM, CHESHIRE
    		STATE:			X0
    		ZIP:			WA14 2DT
    		BUSINESS PHONE:		44 7391 789784

    	MAIL ADDRESS:
    		STREET 1:		3RD FLOOR
    		STREET 2:		1 ASHLEY ROAD
    		CITY:			ALTRINCHAM, CHESHIRE
    		STATE:			X0
    		ZIP:			WA14 2DT

    	FORMER COMPANY:
    		FORMER CONFORMED NAME:	Centessa Pharmaceuticals Ltd
    		DATE OF NAME CHANGE:	20210224
    </SEC-HEADER>
    <DOCUMENT>
    <TYPE>DEF 14A
    <SEQUENCE>1
    <FILENAME>centessa_proxy-2025.htm
    <DESCRIPTION>DEFINITIVE PROXY STATEMENT
    <TEXT>
    Document 1 - file: centessa_proxy-2025.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>2
    <FILENAME>centessa_proxy-2025img001.gif
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 2 - file: centessa_proxy-2025img001.gif

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>3
    <FILENAME>centessa_proxy-2025img002.gif
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 3 - file: centessa_proxy-2025img002.gif

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>4
    <FILENAME>centessa_proxy-2025img003.gif
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 4 - file: centessa_proxy-2025img003.gif

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>5
    <FILENAME>centessa_proxy-2025img004.gif
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 5 - file: centessa_proxy-2025img004.gif

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>6
    <FILENAME>proxy-1.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 6 - file: proxy-1.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>7
    <FILENAME>proxy-2.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 7 - file: proxy-2.jpg

    </DOCUMENT>
    </SEC-DOCUMENT>