<SEC-DOCUMENT>0001969223-25-000613.txt : 20250815
<SEC-HEADER>0001969223-25-000613.hdr.sgml : 20250815
<ACCEPTANCE-DATETIME>20250815160338
ACCESSION NUMBER:		0001969223-25-000613
CONFORMED SUBMISSION TYPE:	144
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20250815
DATE AS OF CHANGE:		20250815

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Centessa Pharmaceuticals plc
		CENTRAL INDEX KEY:			0001847903
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		ORGANIZATION NAME:           	03 Life Sciences
		EIN:				000000000
		STATE OF INCORPORATION:			X0
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		144
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	001-40445
		FILM NUMBER:		251224547

	BUSINESS ADDRESS:	
		STREET 1:		3RD FLOOR
		STREET 2:		1 ASHLEY ROAD
		CITY:			ALTRINCHAM, CHESHIRE
		STATE:			X0
		ZIP:			WA14 2DT
		BUSINESS PHONE:		44 7391 789784

	MAIL ADDRESS:	
		STREET 1:		3RD FLOOR
		STREET 2:		1 ASHLEY ROAD
		CITY:			ALTRINCHAM, CHESHIRE
		STATE:			X0
		ZIP:			WA14 2DT

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	Centessa Pharmaceuticals Ltd
		DATE OF NAME CHANGE:	20210224

REPORTING-OWNER:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			HUSSAIN IQBAL J
		CENTRAL INDEX KEY:			0001862050
		ORGANIZATION NAME:           	

	FILING VALUES:
		FORM TYPE:		144

	MAIL ADDRESS:	
		STREET 1:		C/O CENTESSA PHARMACEUTICALS PLC
		STREET 2:		D. HODGKIN BLDG, BABRAHAM RSRCH CAMPUS
		CITY:			CAMBRIDGE
		STATE:			X0
		ZIP:			CB22 3FH
</SEC-HEADER>
<DOCUMENT>
<TYPE>144
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
<XML>
<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
  <headerData>
    <submissionType>144</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001862050</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <issuerInfo>
      <issuerCik>0001847903</issuerCik>
      <issuerName>Centessa Pharmaceuticals plc</issuerName>
      <secFileNumber>001-40445</secFileNumber>
      <issuerAddress>
        <com:street1>3RD FLOOR</com:street1>
        <com:street2>1 ASHLEY ROAD</com:street2>
        <com:city>ALTRINCHAM, CHESHIRE</com:city>
        <com:stateOrCountry>X0</com:stateOrCountry>
        <com:zipCode>WA14 2DT</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>44 7391 789784</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>HUSSAIN IQBAL J</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Officer</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>UBS Financial Services Inc.</name>
        <address>
          <com:street1>1000 Harbor Blvd</com:street1>
          <com:street2>3rd Floor</com:street2>
          <com:city>Weehawken</com:city>
          <com:stateOrCountry>NJ</com:stateOrCountry>
          <com:zipCode>07086</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>6000</noOfUnitsSold>
      <aggregateMarketValue>103380.00</aggregateMarketValue>
      <noOfUnitsOutstanding>134073436</noOfUnitsOutstanding>
      <approxSaleDate>08/15/2025</approxSaleDate>
      <securitiesExchangeName>Nasdaq</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>08/15/2025</acquiredDate>
      <natureOfAcquisitionTransaction>Exercise of Stock Options</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>6000</amountOfSecuritiesAcquired>
      <paymentDate>08/15/2025</paymentDate>
      <natureOfPayment>Cash</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Iqbal Hussain</name>
        <address>
          <com:street1>3RD FLOOR</com:street1>
          <com:street2>1 ASHLEY ROAD</com:street2>
          <com:city>ALTRINCHAM, CHESHIRE</com:city>
          <com:stateOrCountry>X0</com:stateOrCountry>
          <com:zipCode>WA14 2DT</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>06/24/2025</saleDate>
      <amountOfSecuritiesSold>12000</amountOfSecuritiesSold>
      <grossProceeds>168218.40</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Iqbal Hussain</name>
        <address>
          <com:street1>3RD FLOOR</com:street1>
          <com:street2>1 ASHLEY ROAD</com:street2>
          <com:city>ALTRINCHAM, CHESHIRE</com:city>
          <com:stateOrCountry>X0</com:stateOrCountry>
          <com:zipCode>X0 WA14 2D</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>07/15/2025</saleDate>
      <amountOfSecuritiesSold>6000</amountOfSecuritiesSold>
      <grossProceeds>89566.80</grossProceeds>
    </securitiesSoldInPast3Months>
    <remarks>The transactions reported herein were effected pursuant to a Rule 10b5-1 trading plan</remarks>
    <noticeSignature>
      <noticeDate>08/15/2025</noticeDate>
      <planAdoptionDates>
        <planAdoptionDate>09/14/2024</planAdoptionDate>
      </planAdoptionDates>
      <signature>/s/ UBS Financial Services Inc, as attorney-in-fact for Iqbal Hussain</signature>
    </noticeSignature>
  </formData>
</edgarSubmission>
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</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
