    <SEC-DOCUMENT>0001847903-26-000041-index.html : 20260429
    <SEC-HEADER>0001847903-26-000041.hdr.sgml : 20260429
    <ACCEPTANCE-DATETIME>20260429080303
    ACCESSION NUMBER:		0001847903-26-000041
    CONFORMED SUBMISSION TYPE:	ARS
    PUBLIC DOCUMENT COUNT:		1
    CONFORMED PERIOD OF REPORT:	20251231
    FILED AS OF DATE:		20260429
    DATE AS OF CHANGE:		20260429
    EFFECTIVENESS DATE:		20260429

    FILER:

    	COMPANY DATA:
    		COMPANY CONFORMED NAME:			Centessa Pharmaceuticals plc
    		CENTRAL INDEX KEY:			0001847903
    		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
    		ORGANIZATION NAME:           	03 Life Sciences
    		EIN:				000000000
    		STATE OF INCORPORATION:			X0
    		FISCAL YEAR END:			1231

    	FILING VALUES:
    		FORM TYPE:		ARS
    		SEC ACT:		1934 Act
    		SEC FILE NUMBER:	001-40445
    		FILM NUMBER:		26910634

    	BUSINESS ADDRESS:
    		STREET 1:		3RD FLOOR
    		STREET 2:		1 ASHLEY ROAD
    		CITY:			ALTRINCHAM, CHESHIRE
    		STATE:			X0
    		ZIP:			WA14 2DT
    		BUSINESS PHONE:		44 7391 789784

    	MAIL ADDRESS:
    		STREET 1:		3RD FLOOR
    		STREET 2:		1 ASHLEY ROAD
    		CITY:			ALTRINCHAM, CHESHIRE
    		STATE:			X0
    		ZIP:			WA14 2DT

    	FORMER COMPANY:
    		FORMER CONFORMED NAME:	Centessa Pharmaceuticals Ltd
    		DATE OF NAME CHANGE:	20210224
    </SEC-HEADER>
    <DOCUMENT>
    <TYPE>ARS
    <SEQUENCE>1
    <FILENAME>centessaars-123125.pdf
    <DESCRIPTION>ARS
    <TEXT>
    Document 1 - file: centessaars-123125.pdf

    </DOCUMENT>
    </SEC-DOCUMENT>