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Expenses by nature - Operating expenses (Details) - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2016 | Dec. 31, 2015 | Dec. 31, 2014
Operating expenses: |  |  |
Employee-related expenses | $ 42,260 | $ 31,398 | $ 27,685
Laboratory and development expenses | 21,054 | 10,874 | 8,483
Legal and advisory expenses | 11,715 | 12,209 | 8,137
Office and housing expenses | 10,384 | 7,075 | 4,981
Patents and license expenses | 1,348 | 1,342 | 1,181
Depreciation, amortization and impairment expenses | 6,089 | 6,324 | 2,580
Non-employee share-based compensation expenses | 670 | 6,429 | 4,087
Other operating expenses | 4,989 | 6,857 | 3,711
Total | $ 98,509 | $ 82,508 | $ 60,845

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- Definition Amount of expense provided in the period for legal costs incurred pertaining to resolved, pending or threatened litigation, including arbitration and mediation proceedings and fees charged for services from professionals such as doctors, lawyers and accountants. + References No definition available. + Details
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- Definition The aggregate amount of expenditures for salaries, wages, profit sharing and incentive compensation, and other employee benefits, including equity-based compensation, and pension and other postretirement benefit expense. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 225 -SubTopic 10 -Section S99 -Paragraph 2 -Subparagraph (SX 210.5-03.4) -URI http://asc.fasb.org/extlink&oid=63488584&loc=d3e20235-122688 + Details
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- Definition Costs incurred and are directly related to generating license revenue. Licensing arrangements include, but are not limited to, rights to use a patent, copyright, technology, manufacturing process, software or trademark. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 225 -SubTopic 10 -Section S99 -Paragraph 2 -Subparagraph (SX 210.5-03.2(e)) -URI http://asc.fasb.org/extlink&oid=63488584&loc=d3e20235-122688 + Details
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- Definition The total amount of other operating cost and expense items that are associated with the entity's normal revenue producing operation. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 225 -SubTopic 10 -Section S99 -Paragraph 2 -Subparagraph (SX 210.5-03.3) -URI http://asc.fasb.org/extlink&oid=63488584&loc=d3e20235-122688 + Details
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