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Property, plant and equipment, net (Tables) | 12 Months Ended
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Dec. 31, 2016
Property, plant and equipment, net |
Schedule of property, plant and equipment |
|  | December 31, 2016 |  | December 31, 2015 |
|  | in thousands |
Leasehold improvements |  | $ | 30,582 |  | $ | 18,343 |
Laboratory equipment |  |  | 14,166 |  |  | 14,482 |
Office equipment |  |  | 2,710 |  |  | 3,318 |
Construction-in-progress |  |  | 313 |  |  | 804 |
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
Total property, plant, and equipment |  |  | 47,771 |  |  | 36,947 |
Less accumulated depreciation |  |  | (12,069 | ) |  | (10,936 | )
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
Property, plant and equipment, net |  | $ | 35,702 |  | $ | 26,011 |
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
Summary of long-lived assets by geographic region |
|  | December 31, 2016 |  | December 31, 2015 |
|  | in thousands |
Lexington, MA (US) |  | $ | 19,552 |  | $ | 21,594 |
Europe |  |  | 16,150 |  |  | 4,417 |
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
Total |  | $ | 35,702 |  | $ | 26,011 |
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​

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- Definition Tabular disclosure of long-lived assets, excluding financial instruments, long-term customer relationships of a financial institution, mortgage rights, deferred policy acquisition costs, and deferred tax assets, by geographic areas located in the entity's country of domicile and foreign countries in which the entity holds assets. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 280 -SubTopic 10 -Section 50 -Paragraph 41 -Subparagraph b -URI http://asc.fasb.org/extlink&oid=68060357&loc=d3e9038-108599 + Details
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- Definition Tabular disclosure of physical assets used in the normal conduct of business and not intended for resale. Includes, but is not limited to, balances by class of assets, depreciation and depletion expense and method used, including composite depreciation, and accumulated deprecation. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 360 -SubTopic 10 -Section 50 -Paragraph 1 -URI http://asc.fasb.org/extlink&oid=6391035&loc=d3e2868-110229 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 210 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SX 210.5-02(13)) -URI http://asc.fasb.org/extlink&oid=6877327&loc=d3e13212-122682 + Details
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