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CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS - USD ($) $ in Thousands | 12 Months Ended
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Dec. 31, 2016 | Dec. 31, 2015 | Dec. 31, 2014
CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS |  |  |
License revenues | $ 975 |  |
License revenues from related parties | 3,940 | $ 3,335 | $ 1,173
Collaboration revenues | 7,164 |  |
Collaboration revenues from related parties | 13,019 | 7,243 | 4,968
Total revenues | 25,098 | 10,578 | 6,141
Operating expenses: |  |  |
Research and development expenses | (72,510) | (59,125) | (43,772)
Selling, general and administrative expenses | (25,999) | (23,383) | (17,073)
Total operating expenses | (98,509) | (82,508) | (60,845)
Other income | 1,465 | 779 | 1,022
Loss from operations | (71,946) | (71,151) | (53,682)
Interest income | 70 | 121 | 220
Interest expense | (2,172) | (2,572) | (2,019)
Foreign currency gains / (losses) | 1,034 | (2,496) | 5,148
Other non-operating income / (expense) | 785 | (7,164) | 21
Loss before income tax benefit / (expense) | (72,229) | (83,262) | (50,312)
Income tax benefit / (expense) | (1,145) | 1,179 | 535
Net loss | (73,374) | (82,083) | (49,777)
Other comprehensive income / (loss), net of income tax: |  |  |
Foreign currency translation adjustments net of tax impact of $(1.1) million for the year ended December 31, 2016 (2015: $0.7 million and 2014: $0.5 million) | 271 | (1,556) | (5,387)
Total comprehensive loss | $ (73,103) | $ (83,639) | $ (55,164)
Basic and diluted net loss per common share ($) (in dollars per share) | $ (2.93) | $ (3.72) | $ (2.91)
Weighted average shares used in computing basic and diluted net loss per common share (in shares) | 25,036,465 | 22,082,345 | 17,121,328

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