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Fair value measurement - Hercules loan facility (Details) - USD ($) $ in Thousands | 12 Months Ended
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Dec. 31, 2016 | Dec. 31, 2015 | Dec. 31, 2014
Fair value measurements |  |  |
Gain (Loss) recorded due to changes in fair value of derivative liability | $ (1,865) | $ 8,501 | $ 181
Recurring | Fair value hierarchy Level 3 | Hercules Loan Facility Warrant |  |  |
Fair value measurements |  |  |
Fair value of derivative liability | 0 | 300 |
Recurring | Fair value hierarchy Level 3 | Hercules Loan Facility Warrant | Other nonoperating income (expense) |  |  |
Fair value measurements |  |  |
Gain (Loss) recorded due to changes in fair value of derivative liability | 300 | $ 0 |
Recurring | Fair value hierarchy Level 3 | Hercules Loan Facility Warrant | Black-Scholes |  |  |
Fair value measurements |  |  |
Fair value of derivative liability | 11 |  |
Fair value of derivative liability if there is a ten-percentage-point decrease in the share price | 8 |  |
Fair value of derivative liability if there is a ten-percentage-point decrease in the volatility rate | 8 |  |
Fair value of derivative liability if there is a ten-percentage-point decrease in the term to maturity | 9 |  |
Fair value of derivative liability if there is a ten-percentage-point increase in the share price | 15 |  |
Fair value of derivative liability if there is a ten-percentage-point increase in the volatility rate | 15 |  |
Fair value of derivative liability if there is a ten-percentage-point increase in the term to maturity | $ 13 |  |

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