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Property, plant and equipment, net (Details) - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2016 | Dec. 31, 2015 | Dec. 31, 2014
Property, plant and equipment, net |  |  |
Total property, plant, and equipment | $ 47,771 | $ 36,947 |
Less accumulated depreciation | (12,069) | (10,936) |
Property, plant and equipment, net | 35,702 | 26,011 |
Depreciation | 5,500 | 4,400 | $ 2,000
Leasehold improvements |  |  |
Property, plant and equipment, net |  |  |
Total property, plant, and equipment | 30,582 | 18,343 |
Leasehold improvements | Amsterdam |  |  |
Property, plant and equipment, net |  |  |
Total property, plant, and equipment | 13,000 |  |
Laboratory equipment |  |  |
Property, plant and equipment, net |  |  |
Total property, plant, and equipment | 14,166 | 14,482 |
Office equipment |  |  |
Property, plant and equipment, net |  |  |
Total property, plant, and equipment | 2,710 | 3,318 |
Construction-in-progress |  |  |
Property, plant and equipment, net |  |  |
Total property, plant, and equipment | $ 313 | $ 804 |

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- Definition Amount of accumulated depreciation, depletion and amortization for physical assets used in the normal conduct of business to produce goods and services. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 360 -SubTopic 10 -Section 50 -Paragraph 1 -Subparagraph (c) -URI http://asc.fasb.org/extlink&oid=6391035&loc=d3e2868-110229 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 210 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SX 210.5-02.14) -URI http://asc.fasb.org/extlink&oid=6877327&loc=d3e13212-122682 + Details
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- Definition The amount of expense recognized in the current period that reflects the allocation of the cost of tangible assets over the assets' useful lives. Includes production and non-production related depreciation. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 28 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=66902209&loc=d3e3602-108585 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 360 -SubTopic 10 -Section 50 -Paragraph 1 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=6391035&loc=d3e2868-110229 + Details
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