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Expenses by nature (Tables) | 12 Months Ended
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Dec. 31, 2016
Expenses by nature |
Schedule of operating expenses |
|  | Years ended December 31, |
|  | 2016 |  | 2015 |  | 2014 |
|  | in thousands |
Employee-related expenses |  | $ | 42,260 |  | $ | 31,398 |  | $ | 27,685 |
Laboratory and development expenses |  |  | 21,054 |  |  | 10,874 |  |  | 8,483 |
Legal and advisory expenses |  |  | 11,715 |  |  | 12,209 |  |  | 8,137 |
Office and housing expenses |  |  | 10,384 |  |  | 7,075 |  |  | 4,981 |
Patents and license expenses |  |  | 1,348 |  |  | 1,342 |  |  | 1,181 |
Depreciation, amortization and impairment expenses |  |  | 6,089 |  |  | 6,324 |  |  | 2,580 |
Non-employee share-based compensation expenses |  |  | 670 |  |  | 6,429 |  |  | 4,087 |
Other operating expenses |  |  | 4,989 |  |  | 6,857 |  |  | 3,711 |
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
Total |  | $ | 98,509 |  | $ | 82,508 |  | $ | 60,845 |
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
Schedule of employee-related expenses |
|  | Years ended December 31, |
|  | 2016 |  | 2015 |  | 2014 |
|  | in thousands, except for employee numbers |
Wages and salaries |  | $ | 24,999 |  | $ | 19,274 |  | $ | 15,640 |
Social security costs |  |  | 1,824 |  |  | 1,440 |  |  | 1,257 |
Health insurance |  |  | 1,099 |  |  | 828 |  |  | 348 |
Pension costs—defined contribution plans |  |  | 1,088 |  |  | 608 |  |  | 804 |
Share-based compensation expenses |  |  | 5,544 |  |  | 5,188 |  |  | 4,309 |
Consultant expenses |  |  | 5,873 |  |  | 3,037 |  |  | 5,053 |
Other employee expenses |  |  | 1,833 |  |  | 1,023 |  |  | 274 |
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
Total |  | $ | 42,260 |  | $ | 31,398 |  | $ | 27,685 |
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
Number of employees at the end of the period |  |  | 251 |  |  | 198 |  |  | 162 |

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