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CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2016 | Dec. 31, 2015 | Dec. 31, 2014
Cash flows from operating activities |  |  |
Net loss | $ (73,374) | $ (82,083) | $ (49,777)
Adjustments to reconcile net loss to net cash provided by / (used in) operating activities: |  |  |
Depreciation, amortization and impairments | 6,089 | 6,324 | 2,580
Share-based compensation expense | 6,214 | 11,617 | 8,396
Change in fair value of derivative financial instruments | (1,865) | 8,508 | 23
Unrealized foreign exchange results | (755) | (526) | (4,797)
Change in deferred taxes | 1,145 | (1,179) | (535)
Change in lease incentive | 649 | (577) | 6,518
Changes in operating assets and liabilities: |  |  |
Accounts receivable, prepaid expenses and other current assets | (5,917) | (1,680) | (1,195)
Inventories | 480 | (260) | 882
Accounts payable | 344 | (774) | (321)
Accrued expenses and other liabilities | 499 | 4,929 | 1,796
Deferred revenue | (5,698) | 63,169 | (421)
Net cash provided by / (used in) operating activities | (72,189) | 7,468 | (36,851)
Cash flows from investing activities |  |  |
Restricted cash | (613) |  |
Purchase of intangible assets | (1,884) | (415) | (299)
Purchase of property, plant and equipment | (15,288) | (7,607) | (22,195)
Acquisition of business, net of cash acquired |  |  | (1,448)
Net cash used in investing activities | (17,785) | (8,022) | (23,942)
Cash flows from financing activities |  |  |
Proceeds from issuance of shares | 2,593 | 2,865 | 596
Proceeds from pubic offering of shares, net of issuance costs |  | 82,519 | 84,462
Proceeds from issuance of shares to collaboration partner |  | 75,493 |
Proceeds from borrowings |  |  | 9,542
Repayment of capital lease obligations | (148) | (186) | (207)
Net cash generated from financing activities | 2,445 | 160,691 | 94,393
Currency effect cash and cash equivalents | (1,601) | (3,199) | (1,689)
Net increase / (decrease) in cash and cash equivalents | (89,130) | 156,938 | 31,911
Cash and cash equivalents at beginning of period | 221,626 | 64,688 | 32,777
Cash and cash equivalents at end of period | 132,496 | 221,626 | 64,688
Supplemental cash flow disclosures: |  |  |
Cash paid for interest | 2,345 | 2,082 | 1,626
Non-cash adjustments in purchase of intangible assets and property, plant and equipment | $ 1,174 | $ (792) | $ 411

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