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CONSOLIDATED STATEMENTS OF SHAREHOLDERS' EQUITY - USD ($) $ in Thousands | Common shares BMS on June 12, 2015 | Common shares | Additional paid-in capital BMS on June 12, 2015 | Additional paid-in capital | Accumulated other comprehensive income/(loss) | Accumulated deficit | BMS on June 12, 2015 | Total
--- | --- | --- | --- | --- | --- | --- | --- | ---
Beginning balance at Dec. 31, 2013 |  | $ 798 |  | $ 192,204 | $ 115 | $ (190,824) |  | $ 2,293
Beginning balance (in shares) at Dec. 31, 2013 |  | 12,194,906 |  |  |  |  |  |
Increase (decrease) in shareholders' equity |  |  |  |  |  |  |  |
Loss for the period |  |  |  |  |  | (49,777) |  | (49,777)
Other comprehensive income/(loss) |  |  |  |  | (5,387) |  |  | (5,387)
Initial public / follow-on offering |  | $ 368 |  | 84,094 |  |  |  | 84,462
Initial public / follow-on offering (in shares) |  | 5,400,000 |  |  |  |  |  |
Shares issued as consideration in a business combination |  | $ 13 |  | 2,038 |  |  |  | 2,051
Shares issued as consideration in a business combination (in shares) |  | 192,128 |  |  |  |  |  |
Exercise of share options |  | $ 19 |  | 577 |  |  |  | 596
Exercise of share options (in shares) |  | 305,160 |  |  |  |  |  |
Share-based compensation expense |  |  |  | 8,396 |  |  |  | 8,396
Ending balance at Dec. 31, 2014 |  | $ 1,198 |  | 287,309 | (5,272) | (240,601) |  | 42,634
Ending balance (in shares) at Dec. 31, 2014 |  | 18,092,194 |  |  |  |  |  |
Increase (decrease) in shareholders' equity |  |  |  |  |  |  |  |
Loss for the period |  |  |  |  |  | (82,083) |  | (82,083)
Other comprehensive income/(loss) |  |  |  |  | (1,556) |  |  | (1,556)
Initial public / follow-on offering |  | $ 165 |  | 82,354 |  |  |  | 82,519
Initial public / follow-on offering (in shares) |  | 3,000,000 |  |  |  |  |  |
Issuance of shares to collaboration partner | $ 132 |  | $ 71,799 |  |  |  | $ 71,931 |
Issuance of shares to collaboration partner (in shares) | 2,388,108 |  |  |  |  |  |  |
Exercise of share options |  | $ 47 |  | 2,818 |  |  |  | 2,865
Exercise of share options (in shares) |  | 847,642 |  |  |  |  |  |
Share-based compensation expense |  |  |  | 11,617 |  |  |  | 11,617
Ending balance at Dec. 31, 2015 |  | $ 1,542 |  | 455,897 | (6,828) | (322,684) |  | $ 127,927
Ending balance (in shares) at Dec. 31, 2015 |  | 24,327,944 |  |  |  |  |  | 24,327,944
Increase (decrease) in shareholders' equity |  |  |  |  |  |  |  |
Loss for the period |  |  |  |  |  | (73,374) |  | $ (73,374)
Other comprehensive income/(loss) |  |  |  |  | 271 |  |  | 271
Exercise of share options |  | $ 41 |  | 2,542 |  |  |  | 2,583
Exercise of share options (in shares) |  | 750,408 |  |  |  |  |  |
Restricted share units distributed during the period |  | $ 10 |  |  |  |  |  | 10
Restricted share units distributed during the period (in shares) |  | 179,068 |  |  |  |  |  |
Share-based compensation expense |  |  |  | 6,214 |  |  |  | 6,214
Ending balance at Dec. 31, 2016 |  | $ 1,593 |  | $ 464,653 | $ (6,557) | $ (396,058) |  | $ 63,631
Ending balance (in shares) at Dec. 31, 2016 |  | 25,257,420 |  |  |  |  |  | 25,257,420

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