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Share-based compensation (Tables) | 12 Months Ended
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Dec. 31, 2016
Share-based compensation |
Schedule of share-based compensation expense by classification included in consolidated statements of operations and comprehensive loss |
|  | Years ended December 31, |
|  | 2016 |  | 2015 |  | 2014 |
|  |  |  | in thousands |  |  |
Research and development |  | $ | 3,972 |  | $ | 8,591 |  | $ | 6,563 |
Selling, general and administrative |  |  | 2,242 |  |  | 3,026 |  |  | 1,833 |
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
Total |  | $ | 6,214 |  | $ | 11,617 |  | $ | 8,396 |
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
Research and development, excluding 4D |  |  | 3,302 |  |  | 2,162 |  |  | 2,476 |
Schedule of share-based compensation expense |
|  | Years ended December 31, |
|  | 2016 |  | 2015 |  | 2014 |
|  | in thousands |
Award type |  |  |  |  |  |  |  |  |  |
Share options |  | $ | 5,187 |  | $ | 10,469 |  | $ | 7,966 |
Restricted share units ("RSUs") |  |  | 528 |  |  | 1,148 |  |  | 430 |
Performance share units ("PSUs") |  |  | 499 |  |  | — |  |  | — |
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
Total |  | $ | 6,214 |  | $ | 11,617 |  | $ | 8,396 |
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
Schedule of unrecognized compensation cost related to unvested awards |
|  | Unrecognized compensation costs |  | Weighted-average remaining period for recognition (in years) |
|  | in thousands |  |  |
Award type |  |  |  |  |  |  |
Share options |  | $ | 7,370 |  |  | 2.81 |
Restricted share units |  |  | 2,119 |  |  | 1.79 |
Performance share units |  |  | 488 |  |  | 1.48 |
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
Total |  | $ | 9,977 |  |  | 2.53 |
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
2012 Plan |
Share-based compensation |
Summary of option activity |
|  | 2012 Plan |
|  | Options |  | Weighted average exercise price |  | Weighted average remaining contractual life (in years) |  | Aggregate intrinsic value |
|  |  |  |  |  |  |  | in thousands |
Outstanding at January 1, 2016 |  |  | 1,077,944 |  | € | 4.02 |  |  | 4.15 |  | $ | 13,114 |
Exercised |  |  | (510,547 | ) | € | 3.12 |  |  |  |  |  |  |
Expired |  |  | (84,391 | ) | € | 3.07 |  |  |  |  |  |  |
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
Outstanding, fully vested and exercisable at December 31, 2016 |  |  | 483,006 |  | € | 5.13 |  |  | 4.13 |  | $ | 810 |
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
Summary of information about options exercised |
|  | Exercised during the year |  | Intrinsic value |
|  |  |  | in thousands |
2016 |  |  | 510,547 |  | $ | 4,381 |
2015 |  |  | 449,838 |  |  | 9,272 |
2014 |  |  | 152,724 |  |  | 1,357 |
2014 Plan |
Share-based compensation |
Summary of option activity |
|  | 2014 plan |
|  | Options |  | Weighted average exercise price |  | Weighted average remaining contractual life (in years) |  | Aggregate intrinsic value |
|  |  |  |  |  |  |  | in thousands |
Outstanding at January 1, 2016 |  |  | 1,448,226 |  | $ | 14.05 |  |  | 8.19 |  | $ | 6,522 |
Granted |  |  | 899,178 |  | $ | 11.44 |  |  |  |  |  |  |
Exercised |  |  | (87,425 | ) | $ | 9.36 |  |  |  |  |  |  |
Forfeited |  |  | (407,577 | ) | $ | 16.50 |  |  |  |  |  |  |
Expired |  |  | (39,636 | ) | $ | 12.26 |  |  |  |  |  |  |
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
Outstanding at December 31, 2016 |  |  | 1,812,766 |  | $ | 12.47 |  |  | 7.92 |  | $ | — |
Fully vested and exercisable |  |  | 640,389 |  | $ | 12.57 |  |  | 6.31 |  |  | — |
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
Outstanding and expected to vest |  |  | 1,172,377 |  | $ | 12.41 |  |  | 8.81 |  | $ | — |
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
Summary of information about weighted average grant-date fair value of options granted |
|  | Granted during the year |  | Weighted average grant-date fair value |
2016 |  |  | 899,178 |  | $ | 6.54 |
2015 |  |  | 566,500 |  | $ | 12.19 |
2014 |  |  | 1,115,000 |  | $ | 5.36 |
Schedule of weighted-average assumptions for fair value of option issued |
|  | Years ended December 31, |
Assumptions |  | 2016 |  | 2015 |  | 2014 |
Expected volatility |  |  | 75% |  |  | 75% |  |  | 70% |
Expected terms (in years) |  |  | 10 years |  |  | 6.11 and 10 years |  |  | 6.11 years |
Risk free interest rate |  |  | 0.16% - 2.67% |  |  | 0.57% - 0.62% |  |  | 0.23% |
Expected dividends |  |  | 0% |  |  | 0% |  |  | 0% |
Summary of information about options exercised |
|  | Exercised during the year |  | Intrinsic value |
|  |  |  | in thousands |
2016 |  |  | 87,425 |  | $ | 345 |
2015 |  |  | 92,932 |  |  | 1,697 |
2014 |  |  | — |  |  | — |
Summary of RSUs activity |
|  | Number of shares |  | Weighted average grant-date fair value |
Undistributed at January 1, 2016 |  |  | 179,068 |  | $ | 9.99 |
Granted |  |  | 358,678 |  | $ | 9.05 |
Distributed |  |  | (179,068 | ) | $ | 9.99 |
Forfeited |  |  | (51,615 | ) | $ | 8.67 |
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
Undistributed at December 31, 2016 |  |  | 307,063 |  | $ | 9.11 |
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
Summary of information about weighted average grant-date fair value of RSUs |
|  | Granted during the year |  | Weighted average grant-date fair value |
2016 |  |  | 358,678 |  | $ | 9.05 |
2015 |  |  | — |  |  | N/A |
2014 |  |  | 179,068 |  | $ | 9.99 |
Summary of PSUs activity |
|  | Number of shares |  | Weighted average grant-date fair value |
Undistributed at January 1, 2016 |  |  | — |  | $ | 0.00 |
Granted |  |  | 111,564 |  | $ | 5.76 |
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
Undistributed at December 31, 2016 |  |  | 111,564 |  | $ | 5.76 |
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
Other Plans |
Share-based compensation |
Summary of option activity |
|  | Other plans |
|  | Options |  | Weighted average exercise price |  | Weighted average remaining contractual life (in years) |  | Aggregate intrinsic value |
|  |  |  |  |  |  |  | in thousands |
Outstanding at January 1, 2016 |  |  | 1,152,436 |  | € | 0.05 / $18.36 |  |  | 8.71 |  | $ | 2,513 |
Granted |  |  | 125,000 |  | $ | 12.98 |  |  |  |  |  |  |
Exercised |  |  | (152,436 | ) | € | 0.05 |  |  |  |  |  |  |
Forfeited |  |  | (937,500 | ) | $ | 17.73 |  |  |  |  |  |  |
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
Outstanding at December 31, 2016 |  |  | 187,500 |  | $ | 17.93 |  |  | 6.39 |  | $ | — |
Fully vested and exercisable |  |  | 62,500 |  | $ | 27.82 |  |  | 0.50 |  |  | — |
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
Outstanding and expected to vest |  |  | 125,000 |  | $ | 12.98 |  |  | 9.33 |  | $ | — |
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
Summary of information about weighted average grant-date fair value of options granted |
|  | Granted during the year |  | Weighted average grant-date fair value |
2016 |  |  | 125,000 |  | $ | 7.63 |
2015 |  |  | 1,000,000 |  | $ | 10.60 |
2014 |  |  | 609,744 |  | € | 12.55 |
Summary of information about options exercised |
|  | Exercised during the year |  | Intrinsic value |
|  |  |  | in thousands |
2016 |  |  | 152,436 |  | $ | 2,694 |
2015 |  |  | 304,872 |  |  | 6,155 |
2014 |  |  | 152,436 |  |  | 2,459 |

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