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Shareholders' equity - Extinguishment of derivative obligations (Details) - USD ($) $ / shares in Units, $ in Thousands |  |  | 12 Months Ended |  |
--- | --- | --- | --- | --- | ---
Aug. 07, 2015 | Jun. 12, 2015 | Dec. 31, 2015 | Apr. 15, 2015 | Feb. 05, 2014
Price of shares issued (in dollars per share) |  |  |  | $ 29.50 | $ 17.00
BMS |  |  |  |  |
Balance |  |  | $ 71,931 |  |
BMS | Common shares |  |  |  |  |
Balance |  |  | $ 132 |  |
Balance (in shares) |  |  | 2,388,108 |  |
BMS | Additional paid-in capital |  |  |  |  |
Balance |  |  | $ 71,799 |  |
Collaboration arrangement | BMS |  |  |  |  |
Issuance of shares to collaboration partner | $ 39,300 | $ 32,600 |  |  |
Issuance of shares to collaboration partner (in shares) | 1,300,000 | 1,100,000 |  |  |
Extinguishment of derivative upon issuance of shares to collaboration partner | $ 1,400 | $ 5,000 |  |  |
Price of shares issued (in dollars per share) | $ 29.67 | $ 33.84 |  |  |
BMS on June 12, 2015 |  |  |  |  |
Issuance of shares to collaboration partner |  |  | 71,931 |  |
BMS on June 12, 2015 | Common shares |  |  |  |  |
Issuance of shares to collaboration partner |  |  | $ 132 |  |
Issuance of shares to collaboration partner (in shares) |  |  | 2,388,108 |  |
BMS on June 12, 2015 | Additional paid-in capital |  |  |  |  |
Issuance of shares to collaboration partner |  |  | $ 71,799 |  |
BMS on June 12, 2015 | BMS |  |  |  |  |
Issuance of shares to collaboration partner |  |  | 37,640 |  |
Extinguishment of derivative upon issuance of shares to collaboration partner |  |  | (4,972) |  |
BMS on June 12, 2015 | BMS | Common shares |  |  |  |  |
Issuance of shares to collaboration partner |  |  | $ 61 |  |
Issuance of shares to collaboration partner (in shares) |  |  | 1,112,319 |  |
BMS on June 12, 2015 | BMS | Additional paid-in capital |  |  |  |  |
Issuance of shares to collaboration partner |  |  | $ 37,579 |  |
Extinguishment of derivative upon issuance of shares to collaboration partner |  |  | (4,972) |  |
BMS on August 7, 2015 | BMS |  |  |  |  |
Issuance of shares to collaboration partner |  |  | 37,853 |  |
Extinguishment of derivative upon issuance of shares to collaboration partner |  |  | 1,410 |  |
BMS on August 7, 2015 | BMS | Common shares |  |  |  |  |
Issuance of shares to collaboration partner |  |  | $ 71 |  |
Issuance of shares to collaboration partner (in shares) |  |  | 1,275,789 |  |
BMS on August 7, 2015 | BMS | Additional paid-in capital |  |  |  |  |
Issuance of shares to collaboration partner |  |  | $ 37,782 |  |
Extinguishment of derivative upon issuance of shares to collaboration partner |  |  | $ 1,410 |  |

X
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