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Collaboration arrangements and concentration of credit risk - Revenues (Details) - USD ($) $ in Thousands | 12 Months Ended
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Dec. 31, 2016 | Dec. 31, 2015 | Dec. 31, 2014
Collaboration arrangements |  |  |
Revenues | $ 25,098 | $ 10,578 | $ 6,141
Collaboration arrangement |  |  |
Collaboration arrangements |  |  |
Revenues | 25,098 | 10,578 | 6,141
Collaboration arrangement | BMS |  |  |
Collaboration arrangements |  |  |
Revenues | 16,959 | 4,677 |
Collaboration arrangement | Chiesi Farmaceuticai S.p.A |  |  |
Collaboration arrangements |  |  |
Revenues | $ 8,139 | $ 5,901 | $ 6,141

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- Definition Amount of revenue recognized from goods sold, services rendered, insurance premiums, or other activities that constitute an earning process. Includes, but is not limited to, investment and interest income before deduction of interest expense when recognized as a component of revenue, and sales and trading gain (loss). + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 225 -SubTopic 10 -Section S99 -Paragraph 2 -Subparagraph (SX 210.5-03.1) -URI http://asc.fasb.org/extlink&oid=63488584&loc=d3e20235-122688 + Details
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