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Property, plant and equipment, net | 12 Months Ended
--- | ---
Dec. 31, 2016
Property, plant and equipment, net |
Property, plant and equipment, net | 5 Property, plant and equipment, net
|  | December 31, 2016 |  | December 31, 2015 |
|  | in thousands |
Leasehold improvements |  | $ | 30,582 |  | $ | 18,343 |
Laboratory equipment |  |  | 14,166 |  |  | 14,482 |
Office equipment |  |  | 2,710 |  |  | 3,318 |
Construction-in-progress |  |  | 313 |  |  | 804 |
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
Total property, plant, and equipment |  |  | 47,771 |  |  | 36,947 |
Less accumulated depreciation |  |  | (12,069 | ) |  | (10,936 | )
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
Property, plant and equipment, net |  | $ | 35,702 |  | $ | 26,011 |
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
Investment in new Amsterdam facility In 2016, the Company invested $13.0 million into its new facility located at the Paasheuvelweg in Amsterdam. Construction-in-progress ("CIP") as of December 31, 2016 and 2015 predominantly relates to the build-out of the manufacturing facility in Lexington, MA that began at the end of the second quarter of 2013 and additionally includes the build-out of laboratories in Amsterdam. Total depreciation expense of $5.5 million for the year ended December 31, 2016 (December 31, 2015: $4.4 million, December 31, 2014: $2.0 million) has been charged to research and development expense as it relates to the Company's manufacturing facility and equipment, and the remainder is charged to selling, general and administrative expense. The following table summarizes property, plant and equipment by geographic region.
|  | December 31, 2016 |  | December 31, 2015 |
|  | in thousands |
Lexington, MA (US) |  | $ | 19,552 |  | $ | 21,594 |
Europe |  |  | 16,150 |  |  | 4,417 |
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
Total |  | $ | 35,702 |  | $ | 26,011 |
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​

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- Definition The entire disclosure for long-lived, physical assets used in the normal conduct of business and not intended for resale. Includes, but is not limited to, accounting policies and methodology, roll forwards, depreciation, depletion and amortization expense, including composite depreciation, accumulated depreciation, depletion and amortization expense, useful lives and method used, income statement disclosures, assets held for sale and public utility disclosures. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 210 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SX 210.5-02.13-14) -URI http://asc.fasb.org/extlink&oid=6877327&loc=d3e13212-122682 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 205 -SubTopic 20 -Section 50 -Paragraph 1 -URI http://asc.fasb.org/extlink&oid=64827811&loc=d3e1361-107760 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 360 -SubTopic 10 -Section 50 -Paragraph 2 -URI http://asc.fasb.org/extlink&oid=64862545&loc=d3e2921-110230 Reference 4: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 360 -SubTopic 10 -Section 50 -Paragraph 1 -URI http://asc.fasb.org/extlink&oid=6391035&loc=d3e2868-110229 + Details
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