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Intangible assets - Acquired licenses and acquired In-process research & development (Details) - USD ($) $ in Thousands | 1 Months Ended | 12 Months Ended |
--- | --- | --- | ---
May 31, 2015 | Dec. 31, 2016 | Dec. 31, 2015 | Dec. 31, 2014 | Dec. 31, 2013 | Sep. 30, 2015
Intangible assets |  |  |  |  |  |
Carrying amount |  | $ 8,324 | $ 6,815 |  |  |
Amount paid for intangible asset included in capitalized costs |  | 1,884 | 415 | $ 299 |  |
Licenses |  |  |  |  |  |
Intangible assets |  |  |  |  |  |
Carrying amount |  | 3,847 | 1,914 |  |  |
Amortization expense |  | $ 300 | 400 | 600 |  |
Amortization period (in years) |  | 20 years |  |  |  |
Licenses | Glybera |  |  |  |  |  |
Intangible assets |  |  |  |  |  |
WACC (in percent) |  |  |  |  |  | 13.50%
Licenses | Research and development expenses | Glybera |  |  |  |  |  |
Intangible assets |  |  |  |  |  |
Impairment loss |  |  | 1,300 |  |  |
Licenses | National Institutes of Health |  |  |  |  |  |
Intangible assets |  |  |  |  |  |
Carrying amount |  | $ 738 | 866 |  |  |
Licenses | St. Jude Children's Hospital |  |  |  |  |  |
Intangible assets |  |  |  |  |  |
Carrying amount |  | 659 | 723 |  |  |
Licenses | Protein Sciences Corporation |  |  |  |  |  |
Intangible assets |  |  |  |  |  |
Carrying amount |  | 2,194 | 49 |  |  |
Amount paid for intangible asset included in capitalized costs |  | 2,200 |  |  | $ 100 |
Licenses | Other |  |  |  |  |  |
Intangible assets |  |  |  |  |  |
Carrying amount |  | 256 | 276 |  |  |
Acquired R&D |  |  |  |  |  |
Intangible assets |  |  |  |  |  |
Carrying amount |  | 4,477 | 4,901 |  |  |
Amortization period (in years) | 19 years |  |  |  |  |
Acquired R&D | Research and development expenses |  |  |  |  |  |
Intangible assets |  |  |  |  |  |
Amortization expense |  | $ 300 | $ 200 | $ 0 |  |

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- Definition The aggregate expense charged against earnings to allocate the cost of intangible assets (nonphysical assets not used in production) in a systematic and rational manner to the periods expected to benefit from such assets. As a noncash expense, this element is added back to net income when calculating cash provided by or used in operations using the indirect method. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 350 -SubTopic 30 -Section 45 -Paragraph 2 -URI http://asc.fasb.org/extlink&oid=6388964&loc=d3e16225-109274 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 28 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=66902209&loc=d3e3602-108585 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 350 -SubTopic 30 -Section 50 -Paragraph 2 -Subparagraph (a)(2) -URI http://asc.fasb.org/extlink&oid=66006027&loc=d3e16323-109275 + Details
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- Definition Useful life of finite-lived intangible assets, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days. + References No definition available. + Details
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- Definition Amount after amortization of assets, excluding financial assets and goodwill, lacking physical substance with a finite life. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 350 -SubTopic 30 -Section 50 -Paragraph 2 -Subparagraph (a)(1) -URI http://asc.fasb.org/extlink&oid=66006027&loc=d3e16323-109275 + Details
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