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Property, plant and equipment, net

12 Months Ended

Dec. 31, 2016

Property, plant and equipment, net

Property, plant and equipment, net

5      Property, plant and equipment, net

		December 31, 2016			December 31, 2015
		in thousands
Leasehold improvements		$	30,582		$	18,343
Laboratory equipment			14,166			14,482
Office equipment			2,710			3,318
Construction-in-progress			313			804
​	​	​	​	​	​	​	​
Total property, plant, and equipment			47,771			36,947
Less accumulated depreciation			(12,069	)		(10,936	)
​	​	​	​	​	​	​	​
Property, plant and equipment, net		$	35,702		$	26,011
​	​	​	​	​	​	​	​
​	​	​	​	​	​	​	​

Investment in new Amsterdam facility

        In 2016, the Company invested $13.0 million into its new facility located at the Paasheuvelweg in Amsterdam.

        Construction-in-progress ("CIP") as of December 31, 2016 and 2015 predominantly relates to the build-out of the manufacturing facility in Lexington, MA that began at the end of the second quarter of 2013 and additionally includes the build-out of laboratories in Amsterdam.

        Total depreciation expense of $5.5 million for the year ended December 31, 2016 (December 31, 2015: $4.4 million, December 31, 2014: $2.0 million) has been charged to research and development expense as it relates to the Company's manufacturing facility and equipment, and the remainder is charged to selling, general and administrative expense.

        The following table summarizes property, plant and equipment by geographic region.

		December 31, 2016			December 31, 2015
		in thousands
Lexington, MA (US)		$	19,552		$	21,594
Europe			16,150			4,417
​	​	​	​	​	​	​	​
Total		$	35,702		$	26,011
​	​	​	​	​	​	​	​
​	​	​	​	​	​	​	​

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- References

No definition available.

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- Definition

The entire disclosure for long-lived, physical assets used in the normal conduct of business and not intended for resale. Includes, but is not limited to, accounting policies and methodology, roll forwards, depreciation, depletion and amortization expense, including composite depreciation, accumulated depreciation, depletion and amortization expense, useful lives and method used, income statement disclosures, assets held for sale and public utility disclosures.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 210
-SubTopic 10
-Section S99
-Paragraph 1
-Subparagraph (SX 210.5-02.13-14)
-URI http://asc.fasb.org/extlink&oid=6877327&loc=d3e13212-122682

Reference 2: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 205
-SubTopic 20
-Section 50
-Paragraph 1
-URI http://asc.fasb.org/extlink&oid=64827811&loc=d3e1361-107760

Reference 3: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 360
-SubTopic 10
-Section 50
-Paragraph 2
-URI http://asc.fasb.org/extlink&oid=64862545&loc=d3e2921-110230

Reference 4: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 360
-SubTopic 10
-Section 50
-Paragraph 1
-URI http://asc.fasb.org/extlink&oid=6391035&loc=d3e2868-110229

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