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Collaboration arrangements and concentration of credit risk (Tables)

12 Months Ended

Dec. 31, 2016

Collaboration arrangements and concentration of credit risk

Schedule of collaboration and license revenue

		Years ended December 31,
		2016			2015			2014
		in thousands
Bristol Myers Squibb		$	16,959		$	4,677		$	—
Chiesi Farmaceutici S.p.A			8,139			5,901			6,141
​	​	​	​	​	​	​	​	​	​	​
Total		$	25,098		$	10,578		$	6,141
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Schedule of amounts owed in relation to collaboration

		December 31,
		2016			2015
		in thousands
Bristol Myers Squibb		$	5,500		$	1,009
Chiesi Farmaceutici S.p.A			3,680			3,120
​	​	​	​	​	​	​	​
Total		$	9,180		$	4,129
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