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CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2016
Dec. 31, 2015
Dec. 31, 2014
CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS      
License revenues $ 975    
License revenues from related parties 3,940 $ 3,335 $ 1,173
Collaboration revenues 7,164    
Collaboration revenues from related parties 13,019 7,243 4,968
Total revenues 25,098 10,578 6,141
Operating expenses:      
Research and development expenses (72,510) (59,125) (43,772)
Selling, general and administrative expenses (25,999) (23,383) (17,073)
Total operating expenses (98,509) (82,508) (60,845)
Other income 1,465 779 1,022
Loss from operations (71,946) (71,151) (53,682)
Interest income 70 121 220
Interest expense (2,172) (2,572) (2,019)
Foreign currency gains / (losses) 1,034 (2,496) 5,148
Other non-operating income / (expense) 785 (7,164) 21
Loss before income tax benefit / (expense) (72,229) (83,262) (50,312)
Income tax benefit / (expense) (1,145) 1,179 535
Net loss (73,374) (82,083) (49,777)
Other comprehensive income / (loss), net of income tax:      
Foreign currency translation adjustments net of tax impact of $(1.1) million for the year ended December 31, 2016 (2015: $0.7 million and 2014: $0.5 million) 271 (1,556) (5,387)
Total comprehensive loss $ (73,103) $ (83,639) $ (55,164)
Basic and diluted net loss per common share ($) (in dollars per share) $ (2.93) $ (3.72) $ (2.91)
Weighted average shares used in computing basic and diluted net loss per common share (in shares) 25,036,465 22,082,345 17,121,328