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Fair value measurement - Hercules loan facility (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2016	Dec. 31, 2015	Dec. 31, 2014
Fair value measurements
Gain (Loss) recorded due to changes in fair value of derivative liability	$ (1,865)	$ 8,501	$ 181
Recurring | Fair value hierarchy Level 3 | Hercules Loan Facility Warrant
Fair value measurements
Fair value of derivative liability	0	300
Recurring | Fair value hierarchy Level 3 | Hercules Loan Facility Warrant | Other nonoperating income (expense)
Fair value measurements
Gain (Loss) recorded due to changes in fair value of derivative liability	300	$ 0
Recurring | Fair value hierarchy Level 3 | Hercules Loan Facility Warrant | Black-Scholes
Fair value measurements
Fair value of derivative liability	11
Fair value of derivative liability if there is a ten-percentage-point decrease in the share price	8
Fair value of derivative liability if there is a ten-percentage-point decrease in the volatility rate	8
Fair value of derivative liability if there is a ten-percentage-point decrease in the term to maturity	9
Fair value of derivative liability if there is a ten-percentage-point increase in the share price	15
Fair value of derivative liability if there is a ten-percentage-point increase in the volatility rate	15
Fair value of derivative liability if there is a ten-percentage-point increase in the term to maturity	$ 13

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