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Collaboration arrangements and concentration of credit risk - BMS (Details) $ in Thousands			12 Months Ended
	Jul. 31, 2015 USD ($)	May 21, 2015 USD ($)	Dec. 31, 2016 USD ($) item	Dec. 31, 2015 USD ($)	Dec. 31, 2014 USD ($)	Apr. 06, 2015 USD ($)
Collaboration arrangements
License revenues			$ 975
Collaboration revenues			7,164
Collaboration arrangement | BMS
Collaboration arrangements
Fair value of derivative asset						$ 10,100
Collaborative revenue | BMS
Collaboration arrangements
Collaboration revenues			$ 13,000	$ 2,300	$ 0
License revenue | BMS
Collaboration arrangements
Number of potential targets included in collaborative agreement | item			10
Deferred Revenue		$ 60,100
Up-front payment received		50,000
Fair value of derivative asset		$ 10,100
Expected performance term (in years)			19 years
License revenues			$ 3,900	$ 2,400	$ 0
Royalty term after the first commercial sale			10 years
License revenue | BMS | Minimum
Collaboration arrangements
Royalties percentage receivable			high single digit
License revenue | BMS | Maximum
Collaboration arrangements
Royalties percentage receivable			low double- digit
License revenue | BMS | First Target Selection
Collaboration arrangements
Milestone payments to be received upon achievement			$ 254,000
License revenue | BMS | Second, Third, and Fourth Targets Selection
Collaboration arrangements
Target designation payment received	$ 15,000
License revenue | BMS | Fifth through Tenth Targets Selection
Collaboration arrangements
Maximum target designation payments to which entitled per agreement			16,500
License revenue | BMS | Other Selected Targets
Collaboration arrangements
Milestone payments to be received upon achievement			$ 217,000

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- Definition

Revenue earned during the period relating to collaboration arrangement.

+ References

No definition available.

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- Definition

The royalty percentage receivable by the reporting entity under the license agreement.

+ References

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- Definition

The maximum target designation payments to which the reporting entity is entitled per agreement.

+ References

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Milestone payments to be received upon achievement.

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The number of potential targets included in the collaborative agreement.

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The target designation payment received.

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The up-front payment received as of the effective date of the collaboration agreement,

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Amount of deferred revenue as of balance sheet date. Deferred revenue represents collections of cash or other assets related to a revenue producing activity for which revenue has not yet been recognized. Generally, an entity records deferred revenue when it receives consideration from a customer before achieving certain criteria that must be met for revenue to be recognized in conformity with GAAP.

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Reference 1: http://www.xbrl.org/2003/role/presentationRef
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Revenue earned during the period relating to consideration received from another party for the right to use, but not own, certain of the entity's intangible assets. Licensing arrangements include, but are not limited to, rights to use a patent, copyright, technology, manufacturing process, software or trademark. Licensing fees are generally, but not always, fixed as to amount and not dependent upon the revenue generated by the licensing party. An entity may receive licensing fees for licenses that also generate royalty payments to the entity.

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