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Collaboration arrangements and concentration of credit risk - Chiesi (Details)
$ in Thousands, € in Millions
12 Months Ended
Jun. 30, 2013
EUR (€)
Jun. 30, 2013
USD ($)
Dec. 31, 2016
USD ($)
Dec. 31, 2015
USD ($)
Dec. 31, 2014
USD ($)
Collaboration arrangements          
Collaboration revenues     $ 7,164    
License revenues     975    
Chiesi Farmaceuticai S.p.A          
Collaboration arrangements          
Revenues from product sales     0 $ 300 $ 0
Collaborative revenue | Chiesi Farmaceuticai S.p.A          
Collaboration arrangements          
Collaboration revenues     $ 7,200 4,900 5,000
Percentage of costs to be paid by counterparty     50.00%    
Royalties percentage receivable     mid double digit    
Collaborative revenue | Chiesi Farmaceuticai S.p.A | Minimum          
Collaboration arrangements          
Estimated percentage of sales by counterparty to be retained by reporting entity     25.00%    
Collaborative revenue | Chiesi Farmaceuticai S.p.A | Maximum          
Collaboration arrangements          
Estimated percentage of sales by counterparty to be retained by reporting entity     35.00%    
License revenue | Chiesi Farmaceuticai S.p.A          
Collaboration arrangements          
Up-front payment received € 17.0 $ 22,100      
License revenues     $ 1,000 $ 1,000 $ 1,200