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Property, plant and equipment, net (Details) - USD ($)
$ in Thousands
12 Months Ended
Dec. 31, 2016
Dec. 31, 2015
Dec. 31, 2014
Property, plant and equipment, net      
Total property, plant, and equipment $ 47,771 $ 36,947  
Less accumulated depreciation (12,069) (10,936)  
Property, plant and equipment, net 35,702 26,011  
Depreciation 5,500 4,400 $ 2,000
Leasehold improvements      
Property, plant and equipment, net      
Total property, plant, and equipment 30,582 18,343  
Leasehold improvements | Amsterdam      
Property, plant and equipment, net      
Total property, plant, and equipment 13,000    
Laboratory equipment      
Property, plant and equipment, net      
Total property, plant, and equipment 14,166 14,482  
Office equipment      
Property, plant and equipment, net      
Total property, plant, and equipment 2,710 3,318  
Construction-in-progress      
Property, plant and equipment, net      
Total property, plant, and equipment $ 313 $ 804