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Intangible assets - Finite-lived intangible assets and estimated future amortization expense (Details) - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2016
Dec. 31, 2015
Intangible assets    
Average remaining life (in years) 16 years 2 months 12 days  
Historical costs $ 12,707 $ 10,810
Accumulated amortization (4,383) (3,995)
Carrying amount 8,324 6,815
Estimated future amortization expense    
2017 569  
2018 566  
2019 533  
2020 513  
2021 509  
Thereafter 5,634  
Carrying amount $ 8,324 6,815
Licenses    
Intangible assets    
Average remaining life (in years) 14 years 9 months 18 days  
Historical costs $ 7,799 5,730
Accumulated amortization (3,952) (3,816)
Carrying amount 3,847 1,914
Estimated future amortization expense    
Carrying amount $ 3,847 1,914
Acquired R&D    
Intangible assets    
Average remaining life (in years) 17 years 3 months 18 days  
Historical costs $ 4,908 5,080
Accumulated amortization (431) (179)
Carrying amount 4,477 4,901
Estimated future amortization expense    
Carrying amount $ 4,477 $ 4,901