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Intangible assets - Acquired licenses and acquired In-process research & development (Details) - USD ($)
$ in Thousands
 1 Months Ended 12 Months Ended
May 31, 2015
Dec. 31, 2016
Dec. 31, 2015
Dec. 31, 2014
Dec. 31, 2013
Sep. 30, 2015
Intangible assets            
Carrying amount   $ 8,324 $ 6,815      
Amount paid for intangible asset included in capitalized costs   1,884 415 $ 299    
Licenses            
Intangible assets            
Carrying amount   3,847 1,914      
Amortization expense   $ 300 400 600    
Amortization period (in years)   20 years        
Licenses | Glybera            
Intangible assets            
WACC (in percent)           13.50%
Licenses | Research and development expenses | Glybera            
Intangible assets            
Impairment loss     1,300      
Licenses | National Institutes of Health            
Intangible assets            
Carrying amount   $ 738 866      
Licenses | St. Jude Children's Hospital            
Intangible assets            
Carrying amount   659 723      
Licenses | Protein Sciences Corporation            
Intangible assets            
Carrying amount   2,194 49      
Amount paid for intangible asset included in capitalized costs   2,200     $ 100  
Licenses | Other            
Intangible assets            
Carrying amount   256 276      
Acquired R&D            
Intangible assets            
Carrying amount   4,477 4,901      
Amortization period (in years) 19 years          
Acquired R&D | Research and development expenses            
Intangible assets            
Amortization expense   $ 300 $ 200 $ 0