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Expenses by nature - Operating expenses (Details) - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2016
Dec. 31, 2015
Dec. 31, 2014
Operating expenses:      
Employee-related expenses $ 42,260 $ 31,398 $ 27,685
Laboratory and development expenses 21,054 10,874 8,483
Legal and advisory expenses 11,715 12,209 8,137
Office and housing expenses 10,384 7,075 4,981
Patents and license expenses 1,348 1,342 1,181
Depreciation, amortization and impairment expenses 6,089 6,324 2,580
Non-employee share-based compensation expenses 670 6,429 4,087
Other operating expenses 4,989 6,857 3,711
Total $ 98,509 $ 82,508 $ 60,845