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CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2016
Dec. 31, 2015
Dec. 31, 2014
Cash flows from operating activities      
Net loss $ (73,374) $ (82,083) $ (49,777)
Adjustments to reconcile net loss to net cash provided by / (used in) operating activities:      
Depreciation, amortization and impairments 6,089 6,324 2,580
Share-based compensation expense 6,214 11,617 8,396
Change in fair value of derivative financial instruments (1,865) 8,508 23
Unrealized foreign exchange results (755) (526) (4,797)
Change in deferred taxes 1,145 (1,179) (535)
Change in lease incentive 649 (577) 6,518
Changes in operating assets and liabilities:      
Accounts receivable, prepaid expenses and other current assets (5,917) (1,680) (1,195)
Inventories 480 (260) 882
Accounts payable 344 (774) (321)
Accrued expenses and other liabilities 499 4,929 1,796
Deferred revenue (5,698) 63,169 (421)
Net cash provided by / (used in) operating activities (72,189) 7,468 (36,851)
Cash flows from investing activities      
Restricted cash (613)    
Purchase of intangible assets (1,884) (415) (299)
Purchase of property, plant and equipment (15,288) (7,607) (22,195)
Acquisition of business, net of cash acquired     (1,448)
Net cash used in investing activities (17,785) (8,022) (23,942)
Cash flows from financing activities      
Proceeds from issuance of shares 2,593 2,865 596
Proceeds from pubic offering of shares, net of issuance costs   82,519 84,462
Proceeds from issuance of shares to collaboration partner   75,493  
Proceeds from borrowings     9,542
Repayment of capital lease obligations (148) (186) (207)
Net cash generated from financing activities 2,445 160,691 94,393
Currency effect cash and cash equivalents (1,601) (3,199) (1,689)
Net increase / (decrease) in cash and cash equivalents (89,130) 156,938 31,911
Cash and cash equivalents at beginning of period 221,626 64,688 32,777
Cash and cash equivalents at end of period 132,496 221,626 64,688
Supplemental cash flow disclosures:      
Cash paid for interest 2,345 2,082 1,626
Non-cash adjustments in purchase of intangible assets and property, plant and equipment $ 1,174 $ (792) $ 411