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Leases - Lexington, Massachusetts (Details)
 1 Months Ended 12 Months Ended
Jul. 31, 2013
item
Dec. 31, 2016
USD ($)
Dec. 31, 2015
USD ($)
Dec. 31, 2014
USD ($)
Dec. 31, 2017
ft²
Leases          
Future minimum lease payments   $ 39,355,000      
Lease incentives   11,800,000      
Rent expense   4,400,000 $ 1,800,000 $ 1,500,000  
Current deferred rent   684,000 630,000    
Lease for facility in Lexington, Massachusetts, United States          
Leases          
Number of subsequent renewals | item 2        
Renewal term (in years) 5 years        
Future minimum lease payments   14,400,000      
Lease incentives   7,300,000      
Monthly expense   92,680      
Rent expense   1,100,000 1,100,000    
Total deferred rent   6,200,000 6,900,000    
Current deferred rent   $ 700,000 $ 600,000    
Lease for facility in Lexington, Massachusetts, United States | Forecast          
Leases          
Area of facility subject to lease (in square feet) | ft²         53,000