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Leases - Meibergdreef and Academisch Medisch Centrum ("AMC") campus, Amsterdam (Details) $ in Thousands	Dec. 31, 2016 USD ($) ft² facility	Apr. 30, 2015 ft²	Apr. 30, 2014 ft²
Leases
Future minimum lease payments	$ 39,355
Lease for facility from AMC located at Meibergdreef in Amsterdam, Netherlands
Leases
Number of facilities leased | facility	2
Area of facility subject to lease (in square feet) | ft²	26,000
Future minimum lease payments	$ 300
Lease for office facility from AMC located at AMC campus in Amsterdam, Netherlands
Leases
Area of facility subject to lease (in square feet) | ft²			7,100
Future minimum lease payments	200
Lease for laboratory facility from AMC located at AMC campus in Amsterdam, Netherlands | Jan Snel B.V.
Leases
Area of facility subject to lease (in square feet) | ft²		9,300
Future minimum lease payments	$ 1,000

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Area of land subject to a ground lease.

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Amount of required minimum rental payments for leases having an initial or remaining non-cancelable letter-terms in excess of one year.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 840
-SubTopic 10
-Section 55
-Paragraph 40
-Subparagraph (Note 3)
-URI http://asc.fasb.org/extlink&oid=6584154&loc=d3e38371-112697

Reference 2: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 840
-SubTopic 20
-Section 50
-Paragraph 2
-Subparagraph (a)
-URI http://asc.fasb.org/extlink&oid=6453985&loc=d3e41502-112717

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