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Collaboration arrangements and concentration of credit risk - Revenues (Details) - USD ($) $ in Thousands | 3 Months Ended
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Mar. 31, 2017 | Mar. 31, 2016
Collaboration arrangements |  |
Revenues | $ 3,321 | $ 4,295
BMS | Minimum |  |
Collaboration arrangements |  |
Ownership percentage | 5.00% |
Collaboration arrangement |  |
Collaboration arrangements |  |
Revenues | $ 3,321 | 4,295
Collaboration arrangement | BMS |  |
Collaboration arrangements |  |
Revenues | 1,507 | 2,628
Collaboration arrangement | Chiesi Farmaceuticai S.p.A |  |
Collaboration arrangements |  |
Revenues | $ 1,814 | $ 1,667

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- Definition The percentage of ownership of common stock or equity participation in the investee accounted for under the equity method of accounting. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 323 -SubTopic 10 -Section 50 -Paragraph 3 -Subparagraph (a)(1) -URI http://asc.fasb.org/extlink&oid=66011266&loc=d3e33918-111571 + Details
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