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Share-based compensation (Tables) | 3 Months Ended
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Mar. 31, 2017
Share-based compensation |
Schedule of share-based compensation expense by classification included in consolidated statements of operations and comprehensive loss |
|  | Three months ended March 31, |
|  | 2017 |  | 2016 |
|  | in thousands |
Research and development - employees |  | $ | 687 |  | $ | 859 |
Selling, general and administrative - employees |  | 918 |  | 1,119 |
Research and development - non-employees |  | — |  | 670 |
Total |  | $ | 1,605 |  | $ | 2,648 |
Schedule of share-based compensation expense |
|  | Three months ended March 31, |
|  | 2017 |  | 2016 |
|  | in thousands |
Award type |  |  |  |  |
Share options |  | $ | 826 |  | $ | 2,384 |
Restricted share units (“RSUs”) |  | 516 |  | 152 |
Performance share units (“PSUs”) |  | 263 |  | 112 |
Total |  | $ | 1,605 |  | $ | 2,648 |
Schedule of unrecognized compensation cost related to unvested awards |
|  | Unrecognized compensation costs |  | Weighted-average remaining period for recognition (in years) |
|  | in thousands |  |  |
Award type |  |  |  |  |
Stock options |  | $ | 8,324 |  | 2.85 |
Restricted stock units |  | 3,369 |  | 2.22 |
Performance stock units |  | 2,703 |  | 2.60 |
Total |  | $ | 14,396 |  | 2.66 |
2012 Plan |
Share-based compensation |
Summary of option activity |
|  | 2012 Plan |
|  | Options |  | Weighted average exercise price |
Outstanding at December 31, 2016 |  | 483,006 |  | € | 5.13 |
Exercised |  | (134,974 | ) | € | 3.07 |
Outstanding, fully vested and exercisable at March 31, 2017 |  | 348,032 |  | € | 5.92 |
2014 Plan |
Share-based compensation |
Summary of option activity |
|  | 2014 plan |
|  | Options |  | Weighted average exercise price |
Outstanding at December 31, 2016 |  | 1,812,766 |  | $ | 12.47 |
Granted |  | 508,500 |  | $ | 5.63 |
Forfeited |  | (40,371 | ) | $ | 12.76 |
Expired |  | (12,952 | ) | $ | 18.30 |
Outstanding at March 31, 2017 |  | 2,267,943 |  | $ | 10.90 |
Fully vested and exercisable |  | 746,557 |  | $ | 13.01 |
Outstanding and expected to vest |  | 1,521,386 |  | $ | 9.86 |
Schedule of weighted-average assumptions for fair value of option issued |
|  | Three months ended March 31, |
|  | 2017 |  | 2016 |
Assumptions |  |  |  |  |
Expected volatility |  | 75% |  | 75% |
Expected terms (in years) |  | 10 years |  | 10 years |
Risk free interest rate |  | 2.53% - 2.70% |  | 0.16% - 0.54% |
Expected dividends |  | 0% |  | 0% |
Summary of RSUs activity |
|  | Number of shares |  | Weighted average grant-date fair value |
Undistributed at December 31, 2016 |  | 307,063 |  | $ | 9.11 |
Granted |  | 285,500 |  | $ | 5.95 |
Distributed |  | (25,000 | ) | $ | 18.21 |
Forfeited |  | (375 | ) | $ | 13.03 |
Undistributed at March 31, 2017 |  | 567,188 |  | $ | 7.12 |
Summary of PSUs activity |
|  | Number of shares |  | Weighted average grant-date fair value |
Undistributed at December 31, 2016 |  | 111,564 |  | $ | 5.76 |
Distributed |  | (58,500 | ) | $ | 5.76 |
Undistributed at March 31, 2017 |  | 53,064 |  | $ | 5.76 |
Other Plans |
Share-based compensation |
Summary of option activity |
|  | Other plans |
|  | Options |  | Weighted average exercise price |
Outstanding at December 31, 2016 |  | 187,500 |  | $ | 17.93 |
Granted |  | 150,000 |  | $ | 5.31 |
Outstanding at March 31, 2017 |  | 337,500 |  | $ | 12.32 |
Fully vested and exercisable |  | 62,500 |  | $ | 27.82 |
Outstanding and expected to vest |  | 275,000 |  | $ | 8.80 |

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- Definition Tabular disclosure of the amount of total share-based compensation cost, including the amounts attributable to each share-based compensation plan and any related tax benefits. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (h)(1) -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901 + Details
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- Definition Tabular disclosure of the allocation of equity-based compensation costs to a given line item on the balance sheet and income statement for the period. This may include the reporting line for the costs and the amount capitalized and expensed. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (h)(1) -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 1 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5047-113901 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SAB Topic 14.F) -URI http://asc.fasb.org/extlink&oid=27013229&loc=d3e301413-122809 + Details
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- Definition Tabular disclosure of the number and weighted-average grant date fair value for restricted stock units that were outstanding at the beginning and end of the year, and the number of restricted stock units that were granted, vested, or forfeited during the year. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (c)(1) -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901 + Details
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- Definition Tabular disclosure of the number and weighted-average exercise prices (or conversion ratios) for share options (or share units) that were outstanding at the beginning and end of the year, vested and expected to vest, exercisable or convertible at the end of the year, and the number of share options or share units that were granted, exercised or converted, forfeited, and expired during the year. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (c)(1) -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901 + Details
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- Definition Tabular disclosure of the significant assumptions used during the year to estimate the fair value of stock options, including, but not limited to: (a) expected term of share options and similar instruments, (b) expected volatility of the entity's shares, (c) expected dividends, (d) risk-free rate(s), and (e) discount for post-vesting restrictions. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (f)(2) -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901 + Details
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