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Collaboration arrangements and concentration of credit risk - BMS (Details)
$ in Thousands
3 Months Ended 12 Months Ended
Jul. 31, 2015
USD ($)
Mar. 31, 2017
USD ($)
Mar. 31, 2016
USD ($)
Dec. 31, 2016
USD ($)
item
May 21, 2015
USD ($)
Collaboration arrangements          
License revenues   $ 234 $ 241    
Collaboration revenues   1,580 1,426    
Collaborative revenue | BMS          
Collaboration arrangements          
Collaboration revenues   $ 600 1,700    
License revenue | BMS          
Collaboration arrangements          
Number of potential targets included in collaborative agreement | item       10  
Deferred Revenue         $ 60,100
Expected performance term (in years)   19 years      
License revenues   $ 900 $ 1,000    
Royalty term after the first commercial sale       10 years  
License revenue | BMS | Minimum          
Collaboration arrangements          
Royalties percentage receivable       high single digit  
License revenue | BMS | Maximum          
Collaboration arrangements          
Royalties percentage receivable       low double- digit  
License revenue | BMS | First Target Selection          
Collaboration arrangements          
Milestone payments to be received upon achievement       $ 254,000  
License revenue | BMS | Second, Third, and Fourth Targets Selection          
Collaboration arrangements          
Target designation payment received $ 15,000        
License revenue | BMS | Fifth through Tenth Targets Selection          
Collaboration arrangements          
Maximum target designation payments to which entitled per agreement       16,500  
License revenue | BMS | Other Selected Targets          
Collaboration arrangements          
Milestone payments to be received upon achievement       $ 217,000