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Collaboration arrangements and concentration of credit risk - Chiesi (Details)
$ in Thousands, € in Millions
3 Months Ended 12 Months Ended
Jun. 30, 2013
EUR (€)
Jun. 30, 2013
USD ($)
Mar. 31, 2017
USD ($)
Mar. 31, 2016
USD ($)
Dec. 31, 2016
Collaboration arrangements          
Collaboration revenues     $ 1,580 $ 1,426  
License revenues     234 241  
Chiesi Farmaceuticai S.p.A          
Collaboration arrangements          
Revenues from product sales     0 0  
Collaborative revenue | Chiesi Farmaceuticai S.p.A          
Collaboration arrangements          
Collaboration revenues     1,600 1,400  
Percentage of costs to be paid by counterparty         50.00%
Royalties percentage receivable         mid double digit
Collaborative revenue | Chiesi Farmaceuticai S.p.A | Minimum          
Collaboration arrangements          
Estimated percentage of sales by counterparty to be retained by reporting entity         25.00%
Collaborative revenue | Chiesi Farmaceuticai S.p.A | Maximum          
Collaboration arrangements          
Estimated percentage of sales by counterparty to be retained by reporting entity         35.00%
License revenue | Chiesi Farmaceuticai S.p.A          
Collaboration arrangements          
Up-front payment received € 17.0 $ 22,100      
License revenues     $ 200 $ 200