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Property, plant and equipment, net (Details) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2017	Mar. 31, 2016	Dec. 31, 2016
Property, plant and equipment, net
Total property, plant, and equipment	$ 48,976		$ 47,771
Less accumulated depreciation	(13,735)		(12,069)
Property, plant and equipment, net	35,241		35,702
Depreciation	1,700	$ 1,400
Leasehold improvements
Property, plant and equipment, net
Total property, plant, and equipment	31,286		30,582
Laboratory equipment
Property, plant and equipment, net
Total property, plant, and equipment	14,817		14,166
Office equipment
Property, plant and equipment, net
Total property, plant, and equipment	2,733		2,710
Construction-in-progress
Property, plant and equipment, net
Total property, plant, and equipment	$ 140		$ 313

X

- Definition

Amount of accumulated depreciation, depletion and amortization for physical assets used in the normal conduct of business to produce goods and services.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
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-SubTopic 10
-Section 50
-Paragraph 1
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- Definition

The amount of expense recognized in the current period that reflects the allocation of the cost of tangible assets over the assets' useful lives. Includes production and non-production related depreciation.

+ References

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Amount before accumulated depreciation, depletion and amortization of physical assets used in the normal conduct of business and not intended for resale. Examples include, but are not limited to, land, buildings, machinery and equipment, office equipment, and furniture and fixtures.

+ References

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Amount after accumulated depreciation, depletion and amortization of physical assets used in the normal conduct of business to produce goods and services and not intended for resale. Examples include, but are not limited to, land, buildings, machinery and equipment, office equipment, and furniture and fixtures.

+ References

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