CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS - USD ($) $ in Thousands	3 Months Ended
Mar. 31, 2017	Mar. 31, 2016
CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS
License revenues	$ 234	$ 241
License revenues from related party	949	978
Collaboration revenues	1,580	1,426
Collaboration revenues from related party	558	1,650
Total revenues	3,321	4,295
Operating expenses:
Research and development expenses	(16,994)	(16,706)
Selling, general and administrative expenses	(6,358)	(7,298)
Total operating expenses	(23,352)	(24,004)
Other income	316	445
Loss from operations	(19,715)	(19,264)
Interest income	11	22
Interest expense	(504)	(629)
Foreign currency gains, net	(93)	(2,188)
Other non-operating income, net	29	317
Loss before income tax expense	(20,272)	(21,742)
Income tax benefit / (expense)		(557)
Net loss	(20,272)	(22,299)
Other comprehensive loss, net of income tax:
Foreign currency translation adjustments net of tax impact of $nil for the three months ended March 31, 2017 (three months ended March 31, 2016: $(0.6) million)	322	4,680
Total comprehensive loss	$ (19,950)	$ (17,619)
Basic and diluted net loss per common share (in dollars per share)	$ (0.80)	$ (0.90)
Weighted average shares used in computing basic and diluted net loss per common share (in shares)	25,443,609	24,696,643

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Revenue from multiple-deliverable arrangements that include licensing fees and services revenue from related parties. Licensing revenue is consideration received from another party for the right to use, but not own, certain of the entity's intangible assets. Licensing arrangements include, but are not limited to, rights to use a patent, copyright, technology, manufacturing process, software or trademark. Licensing fees are generally, but not always, fixed as to amount and not dependent upon the revenue generated by the licensing party. An entity may receive licensing fees for licenses that also generate royalty payments to the entity. Services revenue may be derived by providing other, nonspecified, services during the reporting period.

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Net income after adjustments for dividends on preferred stock (declared in the period) and/or cumulative preferred stock (accumulated for the period).

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Generally recurring costs associated with normal operations except for the portion of these expenses which can be clearly related to production and included in cost of sales or services. Includes selling, general and administrative expense.

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Amount after tax and reclassification adjustments of gain (loss) on foreign currency translation adjustments, foreign currency transactions designated and effective as economic hedges of a net investment in a foreign entity and intra-entity foreign currency transactions that are of a long-term-investment nature, attributable to parent entity.

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The total amount of other operating income, the components of which are not separately disclosed on the income statement, from items that are associated with the entity's normal revenue producing operation.

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The aggregate costs incurred (1) in a planned search or critical investigation aimed at discovery of new knowledge with the hope that such knowledge will be useful in developing a new product or service, a new process or technique, or in bringing about a significant improvement to an existing product or process; or (2) to translate research findings or other knowledge into a plan or design for a new product or process or for a significant improvement to an existing product or process whether intended for sale or the entity's use, during the reporting period charged to research and development projects, including the costs of developing computer software up to the point in time of achieving technological feasibility, and costs allocated in accounting for a business combination to in-process projects deemed to have no alternative future use.

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Amount of revenue recognized from goods sold, services rendered, insurance premiums, or other activities that constitute an earning process. Includes, but is not limited to, investment and interest income before deduction of interest expense when recognized as a component of revenue, and sales and trading gain (loss).

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The aggregate total costs related to selling a firm's product and services, as well as all other general and administrative expenses. Direct selling expenses (for example, credit, warranty, and advertising) are expenses that can be directly linked to the sale of specific products. Indirect selling expenses are expenses that cannot be directly linked to the sale of specific products, for example telephone expenses, Internet, and postal charges. General and administrative expenses include salaries of non-sales personnel, rent, utilities, communication, etc.

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Average number of shares or units issued and outstanding that are used in calculating basic and diluted earnings per share (EPS).

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