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Share-based compensation - Compensation cost (Details) - USD ($)
$ in Thousands
3 Months Ended
Mar. 31, 2017
Mar. 31, 2016
Share-based compensation    
Share-based compensation expense $ 1,605 $ 2,648
Unrecognized compensation costs $ 14,396  
Weighted-average remaining period for recognition (in years) 2 years 7 months 28 days  
Research and development expenses | Employees    
Share-based compensation    
Share-based compensation expense $ 687 859
Research and development expenses | Non-employees    
Share-based compensation    
Share-based compensation expense   670
Selling, general and administrative expense | Employees    
Share-based compensation    
Share-based compensation expense 918 1,119
Share options    
Share-based compensation    
Share-based compensation expense 826 2,384
Unrecognized compensation costs $ 8,324  
Weighted-average remaining period for recognition (in years) 2 years 10 months 6 days  
Restricted share units ("RSUs")    
Share-based compensation    
Share-based compensation expense $ 516 152
Unrecognized compensation costs $ 3,369  
Weighted-average remaining period for recognition (in years) 2 years 2 months 19 days  
Performance share units ("PSUs")    
Share-based compensation    
Share-based compensation expense $ 263 $ 112
Unrecognized compensation costs $ 2,703  
Weighted-average remaining period for recognition (in years) 2 years 7 months 6 days