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Share-based compensation (Tables) | 9 Months Ended
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Sep. 30, 2017
Share-based compensation |
Schedule of share-based compensation expense by classification included in consolidated statements of operations and comprehensive loss |
|  | Three months ended September 30, |  | Nine months ended September 30,
|  | 2017 |  | 2016 |  | 2017 |  | 2016
|  | in thousands
Research and development - employees |  | $ | 1,131 |  | $ | 893 |  | $ | 2,612 |  | $ | 2,670
Selling, general and administrative - employees |  |  | 1,316 |  |  | 30 |  |  | 3,366 |  |  | 1,680
Research and development - non-employees |  |  | — |  |  | — |  |  | — |  |  | 670
Total |  | $ | 2,447 |  | $ | 923 |  | $ | 5,978 |  | $ | 5,020
Schedule of share-based compensation expense |
|  | Three months ended September 30, |  | Nine months ended September 30,
|  | 2017 |  | 2016 |  | 2017 |  | 2016
Award type |  | in thousands
Share options |  | $ | 638 |  | $ | 718 |  | $ | 2,347 |  | $ | 4,408
Restricted share units (“RSUs”) |  |  | 728 |  |  | 88 |  |  | 1,960 |  |  | 323
Performance share units (“PSUs”) |  |  | 1,081 |  |  | 117 |  |  | 1,671 |  |  | 289
Total |  | $ | 2,447 |  | $ | 923 |  | $ | 5,978 |  | $ | 5,020
Schedule of unrecognized compensation cost related to unvested awards |
|  |  |  |  | Weighted-average
|  | Unrecognized |  | remaining
|  | compensation |  | period for
|  | costs |  | recognition
Award type |  | in thousands |  | in years
Share options |  | $ | 7,041 |  | 2.52
Restricted share units |  |  | 4,003 |  | 1.64
Performance share units |  |  | 3,747 |  | 1.84
Total |  | $ | 14,791 |  | 2.11
Schedule of weighted-average assumptions for fair value of option issued |
|  | Three months ended September 30, |  | Nine months ended September 30,
Assumptions |  | 2017 |  | 2016 |  | 2017 |  | 2016
Expected volatility |  | 80% |  | 75% |  | 75% - 80% |  | 75%
Expected terms (in years) |  | 10 years |  | 10 years |  | 10 years |  | 10 years
Risk free interest rate |  | 2.40% - 2.48% |  | 1.52% - 1.89% |  | 2.40% - 2.81% |  | 0.16% - 1.96%
Expected dividends |  | 0% |  | 0% |  | 0% |  | 0%
Summary of RSUs activity |
|  |  | RSU
|  |  |  |  | Weighted average
|  |  |  |  | grant-date fair
|  | Number of shares |  | value
Non-vested at December 31, 2016 |  |  | 307,063 |  | $ | 9.11
Granted |  |  | 428,350 |  | $ | 6.00
Vested |  |  | (25,000) |  | $ | 18.21
Forfeited |  |  | (38,550) |  | $ | 7.15
Non-vested at September 30, 2017 |  |  | 671,863 |  | $ | 6.90
Total weighted average grant date fair value of RSUs issued during the period (in $ million) |  |  |  |  | $ | 2.6
Grants during the period to directors and officers |  |  | 255,000 |  | $ | 5.95
Summary of PSUs activity |
|  |  | PSU
|  |  |  |  | Weighted average
|  |  |  |  | grant-date fair
|  | Number of shares |  | value
Non-vested at December 31, 2016 |  |  | 111,564 |  | $ | 5.76
Granted |  |  | 13,000 |  | $ | 4.99
Retired |  |  | (12,000) |  | $ | 5.76
Vested |  |  | (58,500) |  | $ | 5.76
Non-vested at September 30, 2017 |  |  | 54,064 |  | $ | 5.57
PSUs awarded but not yet earned |  |  | 437,060 |  |  |
Total non-vested and discretionary PSUs |  |  | 491,124 |  |  |
Total weighted average grant date fair value of PSUs awarded during the period (in $ million) |  |  |  |  | $ | 2.0
2014 Plan |
Share-based compensation |
Summary of option activity |
|  | 2014 plan
|  |  |  | Weighted average
|  | Options |  | exercise price
Outstanding at December 31, 2016 |  | 1,812,766 |  | $ | 12.47
Granted |  | 949,350 |  | $ | 6.17
Forfeited |  | (348,697) |  | $ | 7.95
Expired |  | (164,106) |  | $ | 14.46
Exercised |  | (8,125) |  | $ | 7.49
Outstanding at September 30, 2017 |  | 2,241,188 |  | $ | 10.38
Fully vested and exercisable |  | 820,522 |  | $ | 12.58
Outstanding and expected to vest |  | 1,420,666 |  | $ | 9.10
Total weighted average grant date fair value of options issued during the period (in $ million) |  |  |  | $ | 3.5
Grants during the period to directors and officers |  | 641,250 |  | $ | 6.43
Proceeds from option sales (in $ million) |  |  |  |  | —
2012 Plan |
Share-based compensation |
Summary of option activity |
|  | 2012 plan
|  |  |  | Weighted average
|  | Options |  | exercise price
Outstanding at December 31, 2016 |  | 483,006 |  | € | 5.13
Exercised |  | (286,804) |  | € | 3.07
Forfeited |  | (5,000) |  | € | 3.07
Expired |  | (9,000) |  | € | 3.07
Outstanding, fully vested and exercisable at September 30, 2017 |  | 182,202 |  | € | 8.52
Other Plans |
Share-based compensation |
Summary of option activity |
|  | Other plans
|  |  |  |  | Weighted average
|  | Options |  | exercise price
Outstanding at December 31, 2016 |  |  | 187,500 |  | $ | 17.93
Granted |  |  | 300,000 |  | $ | 6.90
Expired |  |  | (62,500) |  | $ | 27.82
Outstanding at September 30, 2017 |  |  | 425,000 |  | $ | 8.69
Fully vested and exercisable |  |  | 39,062 |  | $ | 12.98
Outstanding and expected to vest |  |  | 385,938 |  | $ | 8.25
Total weighted average grant date fair value of options issued during the period (in $ million) |  |  |  |  | $ | 1.2

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- Definition Tabular disclosure of the allocation of equity-based compensation costs to a given line item on the balance sheet and income statement for the period. This may include the reporting line for the costs and the amount capitalized and expensed. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (h)(1) -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 1 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5047-113901 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SAB Topic 14.F) -URI http://asc.fasb.org/extlink&oid=27013229&loc=d3e301413-122809 + Details
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