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Shareholders’ equity (Details) - USD ($) $ in Millions | Sep. 15, 2017 | Sep. 30, 2017 | Dec. 31, 2016
--- | --- | --- | ---
Shareholders’ equity |  |  |
Shares authorized under the sales agreement with Leerink | 5,000,000 | 60,000,000 | 60,000,000
Commission fee based on gross proceeds of shares sold | 3.00% |  |
Expenses capitalized related to offering | $ 0.4 |  |

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- Definition The maximum number of common shares permitted to be issued by an entity's charter and bylaws. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 210 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SX 210.5-02(29)) -URI http://asc.fasb.org/extlink&oid=6877327&loc=d3e13212-122682 + Details
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