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Intangible assets (Details) - USD ($) $ in Thousands | 3 Months Ended | 9 Months Ended |
--- | --- | --- | ---
Sep. 30, 2017 | Sep. 30, 2016 | Sep. 30, 2017 | Sep. 30, 2016 | Dec. 31, 2016
Intangible assets |  |  |  |  |
Total intangible assets | $ 14,929 |  | $ 14,929 |  | $ 12,707
Less accumulated amortization | (5,902) |  | (5,902) |  | (4,383)
Intangible assets, net | 9,027 |  | 9,027 |  | 8,324
Amortization expense | 100 | $ 100 | 900 | $ 400 |
Licenses |  |  |  |  |
Intangible assets |  |  |  |  |
Total intangible assets | 9,417 |  | 9,417 |  | 7,799
Acquired research & development |  |  |  |  |
Intangible assets |  |  |  |  |
Total intangible assets | $ 5,512 |  | 5,512 |  | $ 4,908
Chiesi Pharmaceutical | Other Expense |  |  |  |  |
Intangible assets |  |  |  |  |
Amortization expense |  |  | $ 600 |  |

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- Definition The aggregate expense charged against earnings to allocate the cost of intangible assets (nonphysical assets not used in production) in a systematic and rational manner to the periods expected to benefit from such assets. As a noncash expense, this element is added back to net income when calculating cash provided by or used in operations using the indirect method. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 350 -SubTopic 30 -Section 45 -Paragraph 2 -URI http://asc.fasb.org/extlink&oid=6388964&loc=d3e16225-109274 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 28 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=66902209&loc=d3e3602-108585 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 350 -SubTopic 30 -Section 50 -Paragraph 2 -Subparagraph (a)(2) -URI http://asc.fasb.org/extlink&oid=66006027&loc=d3e16323-109275 + Details
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