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Collaboration arrangements and concentration of credit risk - Revenues from and amounts owed with collaboration partners (Details) - USD ($)
$ in Thousands
3 Months Ended 9 Months Ended
Sep. 30, 2017
Sep. 30, 2016
Sep. 30, 2017
Sep. 30, 2016
Dec. 31, 2016
Collaboration arrangements          
Revenues $ 2,260 $ 7,221 $ 10,523 $ 15,967  
Collaboration arrangement          
Collaboration arrangements          
Revenues 2,260 7,221 10,523 15,967  
Amounts owed from partners in relation to the collaboration 1,945   1,945   $ 9,180
Collaboration arrangement | BMS          
Collaboration arrangements          
Revenues 2,260 5,125 5,877 10,396  
Amounts owed from partners in relation to the collaboration $ 1,945   1,945   5,500
Collaboration arrangement | Chiesi Pharmaceutical          
Collaboration arrangements          
Revenues   $ 2,096 $ 4,646 $ 5,571  
Amounts owed from partners in relation to the collaboration         $ 3,680