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Collaboration arrangements and concentration of credit risk - BMS collaboration (Details)
$ in Thousands
3 Months Ended 9 Months Ended 12 Months Ended
Jul. 31, 2015
USD ($)
Sep. 30, 2017
USD ($)
Sep. 30, 2016
USD ($)
Sep. 30, 2017
USD ($)
item
Sep. 30, 2016
USD ($)
Dec. 31, 2016
USD ($)
May 21, 2015
USD ($)
Collaboration arrangements              
License revenues from related party   $ 1,124 $ 993 $ 3,060 $ 2,977    
Collaboration revenues from related party   $ 1,136 $ 4,132 $ 2,817 $ 7,419    
Collaboration arrangement | BMS              
Collaboration arrangements              
Unit of accounting | item       3      
License revenue | BMS              
Collaboration arrangements              
Number of potential targets included in collaborative agreement | item       10      
Deferred Revenue             $ 60,100
Expected performance term (in years)       19 years      
Royalty term after the first commercial sale           10 years  
License revenue | BMS | First Target Selection              
Collaboration arrangements              
Milestone payments to be received upon achievement           $ 254,000  
License revenue | BMS | Second, Third, and Fourth Targets Selection              
Collaboration arrangements              
Target designation payment received $ 15,000            
License revenue | BMS | Fifth through Tenth Targets Selection              
Collaboration arrangements              
Maximum target designation payments to which entitled per agreement           16,500  
License revenue | BMS | Other Selected Targets              
Collaboration arrangements              
Milestone payments to be received upon achievement           $ 217,000