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Collaboration arrangements and concentration of credit risk - Chiesi collaboration (Details)
$ in Thousands, € in Millions
1 Months Ended 3 Months Ended 9 Months Ended 12 Months Ended
Sep. 30, 2013
EUR (€)
Sep. 30, 2013
USD ($)
Jul. 31, 2017
USD ($)
Sep. 30, 2016
USD ($)
Sep. 30, 2017
USD ($)
Sep. 30, 2016
USD ($)
Dec. 31, 2016
Collaboration arrangements              
License revenues       $ 246 $ 8 $ 736  
Percentage of costs to be paid by counterparty             50.00%
Collaboration Revenue       $ 1,850 4,638 $ 4,835  
License revenue | Chiesi Pharmaceutical              
Collaboration arrangements              
Up-front payment received € 17.0 $ 22,100          
Fully released outstanding deferred revenue recorded in other income     $ 13,800        
Glybera | License revenue | Chiesi Pharmaceutical              
Collaboration arrangements              
Reduction to license revenue that was previously amortized and repaid by the Company in accordance with the Termination Agreement         $ 500