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CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS - USD ($)
$ in Thousands
 3 Months Ended 9 Months Ended
Sep. 30, 2017
Sep. 30, 2016
Sep. 30, 2017
Sep. 30, 2016
CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS        
License revenues   $ 246 $ 8 $ 736
License revenues from related party $ 1,124 993 3,060 2,977
Collaboration revenues   1,850 4,638 4,835
Collaboration revenues from related party 1,136 4,132 2,817 7,419
Total revenues 2,260 7,221 10,523 15,967
Operating expenses:        
Research and development expenses (20,103) (16,604) (53,963) (52,531)
Selling, general and administrative expenses (5,584) (5,113) (17,352) (20,245)
Total operating expenses (25,687) (21,717) (71,315) (72,776)
Other income 14,413 336 14,995 1,256
Other expense (261)   (2,901)  
Loss from operations (9,275) (14,160) (48,698) (55,553)
Interest income 10 14 33 51
Interest expense (577) (507) (1,583) (1,685)
Foreign currency gains / (losses), net (681) (496) (1,845) (1,764)
Other non-operating income, net   54 29 701
Loss before income tax expense (10,523) (15,095) (52,064) (58,250)
Income tax expense 278 (177) 278 (401)
Net loss (10,245) (15,272) (51,786) (58,651)
Other comprehensive loss, net of income tax:        
Foreign currency translation adjustments net of tax impact of $0.3 million and $(0.2) million for the three months ended September 30, 2017 and 2016, respectively, and $0.3 million and $(0.4) million for the nine months ended September 30, 2017 and 2016, respectively. 22 2,801 748 3,380
Total comprehensive loss $ (10,223) $ (12,471) $ (51,038) $ (55,271)
Basic and diluted net loss per ordinary share $ (0.40) $ (0.61) $ (2.03) $ (2.35)
Weighted average shares used in computing basic and diluted net loss per ordinary share 25,632,642 25,142,660 25,546,225 24,972,839