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Share-based compensation - Compensation cost (Details) - USD ($) $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2017	Sep. 30, 2016	Sep. 30, 2017	Sep. 30, 2016
Share-based compensation
Share-based compensation expense	$ 2,447	$ 923	$ 5,978	$ 5,020
Unrecognized compensation costs	14,791		$ 14,791
Weighted-average remaining period for recognition (in years)			2 years 1 month 10 days
Research and development expenses | Employees
Share-based compensation
Share-based compensation expense	1,131	893	$ 2,612	2,670
Research and development expenses | Non-employees
Share-based compensation
Share-based compensation expense				670
Selling, general and administrative expense | Employees
Share-based compensation
Share-based compensation expense	1,316	30	3,366	1,680
Share options
Share-based compensation
Share-based compensation expense	638	718	2,347	4,408
Unrecognized compensation costs	7,041		$ 7,041
Weighted-average remaining period for recognition (in years)			2 years 6 months 7 days
Restricted share units ("RSUs")
Share-based compensation
Share-based compensation expense	728	88	$ 1,960	323
Unrecognized compensation costs	4,003		$ 4,003
Weighted-average remaining period for recognition (in years)			1 year 7 months 21 days
Performance share units ("PSUs")
Share-based compensation
Share-based compensation expense	1,081	$ 117	$ 1,671	$ 289
Unrecognized compensation costs	$ 3,747		$ 3,747
Weighted-average remaining period for recognition (in years)			1 year 10 months 2 days

X

- Definition

Represents the expense recognized during the period arising from equity-based compensation arrangements (for example, shares of stock, unit, stock options or other equity instruments) with employees, directors and certain consultants qualifying for treatment as employees.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 718
-SubTopic 10
-Section S99
-Paragraph 1
-Subparagraph (SAB Topic 14.F)
-URI http://asc.fasb.org/extlink&oid=27013229&loc=d3e301413-122809

Reference 2: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 718
-SubTopic 10
-Section 50
-Paragraph 1
-Subparagraph (b)
-URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5047-113901

Reference 3: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 718
-SubTopic 10
-Section 50
-Paragraph 2
-Subparagraph (h)(1)(i)
-URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901

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X

- Definition

Unrecognized cost of unvested share-based compensation awards.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 718
-SubTopic 10
-Section 50
-Paragraph 2
-Subparagraph (i)
-URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901

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- Definition

Weighted average period over which unrecognized compensation is expected to be recognized for equity-based compensation plans, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 718
-SubTopic 10
-Section 50
-Paragraph 2
-Subparagraph (i)
-URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901

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- Definition

Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.

+ References

No definition available.

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