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Collaboration arrangements and concentration of credit risk - BMS collaboration - Narrative (Details) $ in Thousands		1 Months Ended	3 Months Ended		12 Months Ended
	May 21, 2015 USD ($)	Aug. 31, 2015 USD ($)	Mar. 31, 2019 USD ($)	Mar. 31, 2018 USD ($)	Dec. 31, 2018 USD ($)
Collaboration arrangements
Revenue			$ 1,136	$ 3,478
Minimum
Collaboration arrangements
Decrease in revenue			1,800
License revenues from related party
Collaboration arrangements
Revenue			557	2,451
Collaboration revenues from related party
Collaboration arrangements
Revenue			579	$ 1,027
BMS arrangement
Collaboration arrangements
Revenue			$ 461		$ 233
License revenue | Bristol Myers Squibb
Collaboration arrangements
Upfront payment recorded	$ 60,100
Royalty term after the first commercial sale			10 years
Average period for completion of pre-clinical phase			4 years
Average period for completion of clinical development and commercial launch			8 years 6 months
Percentage of increase in probability of all additional targets			10
License revenue | Bristol Myers Squibb | First Target Selection
Collaboration arrangements
Milestone payments to be received upon achievement			$ 254,000
License revenue | Bristol Myers Squibb | Second, Third, and Fourth Targets Selection
Collaboration arrangements
Target designation payment received		$ 15,000
License revenue | Bristol Myers Squibb | Fifth through Tenth Targets Selection
Collaboration arrangements
Maximum target designation payments to which entitled per agreement			16,500
License revenue | Bristol Myers Squibb | Other Selected Targets
Collaboration arrangements
Milestone payments to be received upon achievement			$ 217,000

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