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Share-based compensation - Summary of share-based compensation expense and unrecognized costs (Details) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2019	Mar. 31, 2018	Dec. 31, 2018	Jun. 30, 2018	May 31, 2018
2014 Plan
Share-based compensation
Authorized shares				8,601,471	3,000,000
Share-based compensation expense	$ 4,279	$ 2,527
Unrecognized compensation costs	$ 40,256
Weighted-average remaining period for recognition (in years)	2 years 9 months 26 days
Research and development expenses | 2014 Plan
Share-based compensation
Share-based compensation expense	$ 1,980	806
Selling, general and administrative expense | 2014 Plan
Share-based compensation
Share-based compensation expense	2,298	1,721
Share options | 2014 Plan
Share-based compensation
Share-based compensation expense	$ 2,076	1,059
Outstanding of fully vested share options	2,969,444		2,673,712
Unrecognized compensation costs	$ 22,627
Weighted-average remaining period for recognition (in years)	3 years 3 months
Share options | 2012 Plan
Share-based compensation
Outstanding of fully vested share options	14,000		32,567
Restricted share units ("RSUs") | 2014 Plan
Share-based compensation
Share-based compensation expense	$ 930	746
Unrecognized compensation costs	$ 7,968
Weighted-average remaining period for recognition (in years)	2 years 3 months 22 days
Performance share units ("PSUs") | 2014 Plan
Share-based compensation
Share-based compensation expense	$ 1,272	$ 722
Unrecognized compensation costs	$ 9,661
Weighted-average remaining period for recognition (in years)	2 years 2 months 19 days

X

- Definition

Represents the expense recognized during the period arising from equity-based compensation arrangements (for example, shares of stock, unit, stock options or other equity instruments) with employees, directors and certain consultants qualifying for treatment as employees.

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- Definition

Unrecognized cost of unvested share-based compensation awards.

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- Definition

Weighted average period over which unrecognized compensation is expected to be recognized for equity-based compensation plans, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days.

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Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.

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- Definition

The maximum number of shares (or other type of equity) originally approved (usually by shareholders and board of directors), net of any subsequent amendments and adjustments, for awards under the equity-based compensation plan. As stock or unit options and equity instruments other than options are awarded to participants, the shares or units remain authorized and become reserved for issuance under outstanding awards (not necessarily vested).

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Number of options outstanding, including both vested and non-vested options.

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