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Basic and diluted earnings per share (Details) - shares	3 Months Ended
	Mar. 31, 2019	Mar. 31, 2018
Basic and diluted earnings per share
Total potential dilutive ordinary shares	12,678,857	11,032,239
ESPP
Basic and diluted earnings per share
Total potential dilutive ordinary shares	471
Warrants
Basic and diluted earnings per share
Total potential dilutive ordinary shares		37,175
Warrants | Bristol Myers Squibb
Basic and diluted earnings per share
Total potential dilutive ordinary shares	8,830,000	6,950,000
Stock options | 2014 Plan
Basic and diluted earnings per share
Total potential dilutive ordinary shares	2,969,444	2,876,475
Stock options | 2012 Plan
Basic and diluted earnings per share
Total potential dilutive ordinary shares	14,000	63,818
Non-vested and earned RSUs and PSUs
Basic and diluted earnings per share
Total potential dilutive ordinary shares	864,942	1,104,771

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- Definition

Securities (including those issuable pursuant to contingent stock agreements) that could potentially dilute basic earnings per share (EPS) or earnings per unit (EPU) in the future that were not included in the computation of diluted EPS or EPU because to do so would increase EPS or EPU amounts or decrease loss per share or unit amounts for the period presented.

+ References

Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 260
-SubTopic 10
-Section 50
-Paragraph 1
-Subparagraph (c)
-URI http://asc.fasb.org/extlink&oid=6371337&loc=d3e3550-109257

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+ References

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