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Collaboration arrangements and concentration of credit risk - BMS collaboration - Narrative (Details) $ in Thousands |  | 1 Months Ended | 3 Months Ended | 6 Months Ended | 12 Months Ended
--- | --- | --- | --- | --- | ---
May 21, 2015 USD ($) | Aug. 31, 2015 USD ($) | Jun. 30, 2019 USD ($) | Jun. 30, 2018 USD ($) | Jun. 30, 2019 USD ($) | Jun. 30, 2018 USD ($) | Dec. 31, 2018 USD ($)
Collaboration arrangements |  |  |  |  |  |  |
License revenues from related party |  |  | $ 2,100 | $ 2,100 | $ 2,700 | $ 4,600 |
Revenue |  |  | 2,474 | 3,050 | 3,610 | 6,528 |
Minimum |  |  |  |  |  |  |
Collaboration arrangements |  |  |  |  |  |  |
Decrease in revenue |  |  |  |  | 1,900 |  |
License revenues from related party |  |  |  |  |  |  |
Collaboration arrangements |  |  |  |  |  |  |
Revenue |  |  | 2,108 | 2,123 | 2,665 | 4,574 |
Collaboration revenues from related party |  |  |  |  |  |  |
Collaboration arrangements |  |  |  |  |  |  |
Revenue |  |  | $ 366 | $ 927 | 945 | $ 1,954 |
BMS arrangement |  |  |  |  |  |  |
Collaboration arrangements |  |  |  |  |  |  |
Revenue |  |  |  |  | $ 355 |  | $ 233
License revenue | Bristol Myers Squibb |  |  |  |  |  |  |
Collaboration arrangements |  |  |  |  |  |  |
Upfront payment recorded | $ 60,100 |  |  |  |  |  |
Expected performance term if no exclusivity |  |  |  |  | 10 years |  |
Average period for completion of pre-clinical phase |  |  |  |  | 4 years |  |
Average period for completion of clinical development and commercial launch |  |  |  |  | 8 years 6 months |  |
Percentage of increase in probability of all additional targets |  |  |  |  | 10 |  |
License revenue | Bristol Myers Squibb | First Target Selection |  |  |  |  |  |  |
Collaboration arrangements |  |  |  |  |  |  |
Milestone payments to be received upon achievement |  |  |  |  | $ 254,000 |  |
License revenue | Bristol Myers Squibb | Second, Third, and Fourth Targets Selection |  |  |  |  |  |  |
Collaboration arrangements |  |  |  |  |  |  |
Target designation payment received |  | $ 15,000 |  |  |  |  |
License revenue | Bristol Myers Squibb | Fifth through Tenth Targets Selection |  |  |  |  |  |  |
Collaboration arrangements |  |  |  |  |  |  |
Maximum target designation payments to which entitled per agreement |  |  |  |  | 16,500 |  |
License revenue | Bristol Myers Squibb | Other Selected Targets |  |  |  |  |  |  |
Collaboration arrangements |  |  |  |  |  |  |
Milestone payments to be received upon achievement |  |  |  |  | $ 217,000 |  |

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