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Collaboration arrangements and concentration of credit risk - Amounts owed by BMS (Details) $ in Thousands	1 Months Ended	3 Months Ended		6 Months Ended		12 Months Ended
	May 31, 2015 item	Jun. 30, 2019 USD ($) shares	Jun. 30, 2018 USD ($)	Jun. 30, 2019 USD ($) item shares	Jun. 30, 2018 USD ($)	Dec. 31, 2018 USD ($) shares
Revenue, Initial Application Period Cumulative Effect Transition [Line Items]
Common Stock, Shares, Outstanding | shares		37,839,833		37,839,833		37,351,653
Total revenues		$ 2,474	$ 3,050	$ 3,610	$ 6,528
Amounts owed in relation to the collaboration services		355		355		$ 233
BMS arrangement
Revenue, Initial Application Period Cumulative Effect Transition [Line Items]
Total revenues				355		233
BMS arrangement | Bristol Myers Squibb
Revenue, Initial Application Period Cumulative Effect Transition [Line Items]
Number of collaboration targets | item	4
Amounts owed in relation to the collaboration services		$ 355		$ 355		$ 233
BMS arrangement | Maximum | Bristol Myers Squibb
Revenue, Initial Application Period Cumulative Effect Transition [Line Items]
Number of collaboration targets | item				10

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