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Right-of-use asset and lease liabilities - Operating lease liabilities (Details)
$ in Thousands
 3 Months Ended 6 Months Ended
Jun. 30, 2019
USD ($)
$ / €
Jun. 30, 2018
USD ($)
Jun. 30, 2019
USD ($)
$ / €
Jun. 30, 2018
USD ($)
Jan. 01, 2019
USD ($)
Dec. 31, 2018
USD ($)
$ / €
Components of lease cost            
Operating lease cost $ 1,022   $ 1,919      
Variable lease cost 101   182      
Sublease income (264)   (532)      
Total lease cost 859 $ 700 1,569 $ 1,400    
Assets            
Operating lease right-of-use assets 27,173   27,173      
Current liabilities            
Current operating lease liability 4,256   4,256      
Non-current liabilities            
Non-current operating lease liability 31,870   31,870      
Total lease liabilities $ 36,126   $ 36,126      
Weighted-average remaining lease term, Operating leases 10 years 10 months 24 days   10 years 10 months 24 days      
Weighted-average discount rate, Operating leases 11.35%   11.35%      
Supplemental cash flow information related to leases            
Cash paid for amounts included in the measurement of lease liabilities, Operating cash flows for operating leases $ 603   $ 2,016      
Right-of-use asset obtained in exchange for lease obligation            
Operating lease 8,634   8,634      
Amount capitalized of right-of-use assets     19,000      
Undiscounted Cash Flows            
2019 (nine months remaining) 3,088   3,088      
2020 5,278   5,278      
2021 5,373   5,373      
2022 5,470   5,470      
2023 5,568   5,568      
Thereafter 40,235   40,235      
Total minimum lease payments 65,012   65,012      
Less: amount of lease payments representing interest (28,886)   (28,886)      
Total lease liabilities 36,126   36,126      
Less: current obligations under operating leases (4,256)   (4,256)      
Non-current operating lease liability 31,870   31,870      
Landlord incentive payments $ 1,500   $ 1,500      
Exchange rate (in USD per Euro) | $ / € 1.13709   1.13709     1.14449
ASU 2016-02            
Assets            
Operating lease right-of-use assets         $ 19,000  
Non-current liabilities            
Total lease liabilities         28,100  
Undiscounted Cash Flows            
2019 (nine months remaining)           $ 4,670
2020           5,330
2021           5,425
2022           5,522
2023           5,620
Thereafter           40,977
Total minimum lease payments           67,544
Total lease liabilities         $ 28,100  
Lexington            
Current liabilities            
Current operating lease liability $ 1,859   $ 1,859      
Non-current liabilities            
Non-current operating lease liability 20,972   20,972      
Total lease liabilities 22,831   22,831      
Undiscounted Cash Flows            
2019 (nine months remaining) 1,650   1,650      
2020 3,360   3,360      
2021 3,455   3,455      
2022 3,552   3,552      
2023 3,650   3,650      
Thereafter 24,892   24,892      
Total minimum lease payments 40,559   40,559      
Less: amount of lease payments representing interest (17,728)   (17,728)      
Total lease liabilities 22,831   22,831      
Less: current obligations under operating leases (1,859)   (1,859)      
Non-current operating lease liability 20,972   20,972      
Lexington | ASU 2016-02            
Undiscounted Cash Flows            
2019 (nine months remaining)           2,707
2020           3,360
2021           3,455
2022           3,552
2023           3,650
Thereafter           24,892
Total minimum lease payments           41,616
Amsterdam            
Current liabilities            
Current operating lease liability 2,397   2,397      
Non-current liabilities            
Non-current operating lease liability 10,898   10,898      
Total lease liabilities 13,295   13,295      
Undiscounted Cash Flows            
2019 (nine months remaining) 1,438   1,438      
2020 1,918   1,918      
2021 1,918   1,918      
2022 1,918   1,918      
2023 1,918   1,918      
Thereafter 15,343   15,343      
Total minimum lease payments 24,453   24,453      
Less: amount of lease payments representing interest (11,158)   (11,158)      
Total lease liabilities 13,295   13,295      
Less: current obligations under operating leases (2,397)   (2,397)      
Non-current operating lease liability $ 10,898   $ 10,898      
Amsterdam | ASU 2016-02            
Undiscounted Cash Flows            
2019 (nine months remaining)           1,963
2020           1,970
2021           1,970
2022           1,970
2023           1,970
Thereafter           16,085
Total minimum lease payments           $ 25,926