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Share-based compensation - Summary of share-based compensation expense and unrecognized costs (Details) - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2019	Jun. 30, 2018	Jun. 30, 2019	Jun. 30, 2018	Dec. 31, 2018	May 31, 2018
2014 Plan
Share-based compensation
Authorized shares		8,601,471		8,601,471		3,000,000
Share-based compensation expense	$ 4,576	$ 2,205	$ 8,854	$ 4,732
Increase in share-based compensation expense	2,400		4,100
Unrecognized compensation costs	38,517		$ 38,517
Weighted-average remaining period for recognition (in years)			2 years 7 months 28 days
Research and development expenses | 2014 Plan
Share-based compensation
Share-based compensation expense	2,119	993	$ 4,099	1,799
Selling, general and administrative expense | 2014 Plan
Share-based compensation
Share-based compensation expense	2,457	1,212	4,755	2,933
Share options | 2014 Plan
Share-based compensation
Share-based compensation expense	$ 2,004	1,096	$ 4,080	2,155
Outstanding of fully vested share options	2,943,756		2,943,756		2,673,712
Unrecognized compensation costs	$ 21,695		$ 21,695
Weighted-average remaining period for recognition (in years)			3 years 29 days
Share options | 2012 Plan
Share-based compensation
Outstanding of fully vested share options	14,000		14,000		32,567
Restricted share units ("RSUs") | 2014 Plan
Share-based compensation
Share-based compensation expense	$ 995	540	$ 1,925	1,286
Unrecognized compensation costs	6,955		$ 6,955
Weighted-average remaining period for recognition (in years)			2 years 1 month 6 days
Performance share units ("PSUs") | 2014 Plan
Share-based compensation
Share-based compensation expense	1,577	$ 569	$ 2,849	$ 1,291
Unrecognized compensation costs	$ 9,867		$ 9,867
Weighted-average remaining period for recognition (in years)			2 years 1 month 13 days

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The amount of increase (decrease) in share based compensation expense.

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Amount of expense for award under share-based payment arrangement. Excludes amount capitalized.

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Amount of cost not yet recognized for nonvested award under share-based payment arrangement.

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Weighted-average period over which cost not yet recognized is expected to be recognized for award under share-based payment arrangement, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents reported fact of one year, five months, and thirteen days.

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Number of shares authorized for issuance under share-based payment arrangement.

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Number of options outstanding, including both vested and non-vested options.

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