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CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS - USD ($)
$ in Thousands
 3 Months Ended 6 Months Ended
Jun. 30, 2019
Jun. 30, 2018
Jun. 30, 2019
Jun. 30, 2018
Total revenues $ 2,474 $ 3,050 $ 3,610 $ 6,528
Operating expenses:        
Research and development expenses (24,154) (18,493) (44,691) (35,551)
Selling, general and administrative expenses (7,870) (5,896) (15,937) (12,197)
Total operating expenses (32,024) (24,389) (60,628) (47,748)
Other income 566 565 879 1,180
Other expense (347) (429) (696) (762)
Loss from operations (29,331) (21,203) (56,835) (40,802)
Interest income 728 583 1,170 836
Interest expense (937) (565) (1,894) (981)
Foreign currency (losses) / gains, net (1,252) 2,255 1,022 2,433
Other non-operating loss, net (607) (1,301) (2,634) (598)
Loss before income tax expense (31,399) (20,231) (59,171) (39,112)
Income tax expense   (361)   (269)
Net loss (31,399) (20,592) (59,171) (39,381)
Other comprehensive income / (loss), net of income tax:        
Foreign currency translation adjustments net of tax impact of nil and $0.4 million for the three months ended June 30, 2019 and 2018, respectively, and nil and $0.3 million for the six months ended June 30, 2019 and 2018, respectively. 1,209 (3,376) (1,259) (2,692)
Total comprehensive loss $ (30,190) $ (23,968) $ (60,430) $ (42,073)
Basic and diluted net loss per ordinary share $ (830) $ (570) $ (1,570) $ (1,160)
Weighted average shares used in computing basic and diluted net loss per ordinary share 37,824,928 36,205,061 37,750,961 33,970,195
License revenues from related party        
Total revenues $ 2,108 $ 2,123 $ 2,665 $ 4,574
Collaboration revenues from related party        
Total revenues $ 366 $ 927 $ 945 $ 1,954