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CONSOLIDATED STATEMENTS OF SHAREHOLDERS' EQUITY - USD ($)
$ in Thousands
Ordinary shares
Additional paid-in capital
Accumulated other comprehensive (loss)/income
Accumulated deficit
Total
Beginning balance at Dec. 31, 2017 $ 1,947 $ 566,530 $ (3,800) $ (475,318) $ 89,359
Beginning balance (in shares) at Dec. 31, 2017 31,339,040        
Increase (decrease) in shareholders' equity          
Cumulative effect of retroactive implementation of ASC 606 Revenue recognition     1,802 23,116 24,918
Loss for the period       (39,381) (39,381)
Other comprehensive loss     (2,690)   (2,690)
Follow-on public offering $ 309 138,182     138,491
Follow-on public offering (in shares) 5,175,000        
Exercise of share options $ 12 2,975     2,987
Exercise of share options (in shares) 267,753        
Restricted and performance share units distributed during the period $ 20 (20)      
Restricted and performance share units distributed during the period (in shares) 344,948        
Share-based compensation expense   4,732     4,732
Ending balance at Jun. 30, 2018 $ 2,288 712,399 (4,688) (491,583) 218,416
Ending balance (in shares) at Jun. 30, 2018 37,126,741        
Beginning balance at Mar. 31, 2018 $ 1,971 570,595 (1,312) (470,991) 100,263
Beginning balance (in shares) at Mar. 31, 2018 31,771,816        
Increase (decrease) in shareholders' equity          
Loss for the period       (20,592) (20,592)
Other comprehensive loss     (3,376)   (3,376)
Follow-on public offering $ 309 138,182     138,491
Follow-on public offering (in shares) 5,175,000        
Exercise of share options $ 5 1,420     1,425
Exercise of share options (in shares) 121,592        
Restricted and performance share units distributed during the period $ 3 (3)      
Restricted and performance share units distributed during the period (in shares) 58,333        
Share-based compensation expense   2,205     2,205
Ending balance at Jun. 30, 2018 $ 2,288 712,399 (4,688) (491,583) 218,416
Ending balance (in shares) at Jun. 30, 2018 37,126,741        
Beginning balance at Dec. 31, 2018 $ 2,299 720,072 (7,259) (535,506) $ 179,606
Beginning balance (in shares) at Dec. 31, 2018 37,351,653       37,351,653
Increase (decrease) in shareholders' equity          
Loss for the period       (59,171) $ (59,171)
Other comprehensive loss     (1,259)   (1,259)
Hercules warrants exercise $ 2 1,271     1,273
Hercules warrants exercise (in shares) 37,175        
Exercise of share options $ 14 2,542     2,556
Exercise of share options (in shares) 236,654        
Restricted and performance share units distributed during the period $ 12 (12)      
Restricted and performance share units distributed during the period (in shares) 209,481        
Share-based compensation expense   8,886     8,886
Issuance of ordinary shares relating to employee stock purchase plan   165     165
Issuance of ordinary shares relating to employee stock purchase plan (in shares) 4,870        
Ending balance at Jun. 30, 2019 $ 2,327 732,924 (8,518) (594,677) $ 132,056
Ending balance (in shares) at Jun. 30, 2019 37,839,833       37,839,833
Beginning balance at Mar. 31, 2019 $ 2,322 727,795 (9,727) (563,278) $ 157,112
Beginning balance (in shares) at Mar. 31, 2019 37,763,842        
Increase (decrease) in shareholders' equity          
Loss for the period       (31,399) (31,399)
Other comprehensive loss     1,209   1,209
Exercise of share options $ 4 454     458
Exercise of share options (in shares) 52,847        
Restricted and performance share units distributed during the period $ 1 (1)      
Restricted and performance share units distributed during the period (in shares) 21,400        
Share-based compensation expense   4,592     4,592
Issuance of ordinary shares relating to employee stock purchase plan   84     84
Issuance of ordinary shares relating to employee stock purchase plan (in shares) 1,744        
Ending balance at Jun. 30, 2019 $ 2,327 $ 732,924 $ (8,518) $ (594,677) $ 132,056
Ending balance (in shares) at Jun. 30, 2019 37,839,833       37,839,833