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CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($)
$ in Thousands
 6 Months Ended
Jun. 30, 2019
Jun. 30, 2018
Cash flows from operating activities    
Net loss $ (59,171) $ (39,381)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization 3,217 3,211
Share-based compensation expense 8,886 4,732
Change in fair value of derivative financial instruments and contingent consideration 2,634 517
Unrealized foreign exchange gains (386) (3,417)
Change in deferred taxes   269
Change in lease incentives   (52)
Changes in operating assets and liabilities:    
Accounts receivable and accrued income, prepaid expenses and other current assets (2,779) (202)
Accounts payable 283 717
Accrued expenses, other liabilities and operating leases (658) 208
Deferred revenue (2,683) (4,579)
Net cash used in operating activities (50,657) (37,977)
Cash flows from investing activities    
Purchases of intangible assets (996) (1,445)
Purchases of property, plant and equipment (1,432) (1,197)
Net cash used in investing activities (2,428) (2,642)
Cash flows from financing activities    
Proceeds from issuance of shares related to employee stock option and purchase plans 2,721 2,987
Proceeds from pubic offering of shares, net of issuance costs   138,491
Proceeds from exercise of warrants 500  
Net cash generated from financing activities 3,221 141,478
Currency effect cash, cash equivalents and restricted cash (443) (1,071)
Net (decrease) / increase in cash, cash equivalents and restricted cash (50,307) 99,787
Cash, cash equivalents and restricted cash at beginning of period 237,342 161,851
Cash, cash equivalents and restricted cash at the end of period 187,035 261,638
Total cash, cash equivalents and restricted cash 237,342 161,851
Supplemental cash flow disclosures:    
Cash paid for interest (1,544) (851)
Non-cash increases / (decreases) in accounts payables related to purchase of intangible assets and property, plant and equipment $ 473 $ 316