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Shareholders' equity (Details) - USD ($) $ / shares in Units, $ in Thousands |  | 2 Months Ended | 3 Months Ended | 6 Months Ended |
--- | --- | --- | --- | --- | ---
Mar. 01, 2021 | Apr. 30, 2021 | Jun. 30, 2021 | Jun. 30, 2021 | Dec. 31, 2020
Aggregate offering price |  |  | $ 1,865 | $ 29,564 |
Additional paid-in-capital |  |  | 1,062,234 | 1,062,234 | $ 1,016,018
Cash consideration paid |  |  |  | 46,300 |
Sales Agreement with SVB Leerink LLC |  |  |  |  |
Percentage of gross proceeds | 3.00% |  |  |  |
Net proceeds |  | $ 29,600 |  |  |
Sales Agreement with SVB Leerink LLC | Direct Incremental Labor |  |  |  |  |
Adjustments to Additional Paid in Capital, Stock Issued, Issuance Costs |  |  | $ 300 | $ 1,300 |
Sales Agreement with SVB Leerink LLC | Ordinary shares |  |  |  |  |
Shares issued in connection with offering |  | 921,730 |  |  |
Share price (in dollars per share) |  | $ 33.52 |  |  |
Sales Agreement with SVB Leerink LLC | Maximum |  |  |  |  |
Aggregate offering price | $ 200,000 |  |  |  |

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- Definition Excess of issue price over par or stated value of the entity's capital stock and amounts received from other transactions involving the entity's stock or stockholders. Includes adjustments to additional paid in capital. Some examples of such adjustments include recording the issuance of debt with a beneficial conversion feature and certain tax consequences of equity instruments awarded to employees. Use this element for the aggregate amount of additional paid-in capital associated with common and preferred stock. For additional paid-in capital associated with only common stock, use the element additional paid in capital, common stock. For additional paid-in capital associated with only preferred stock, use the element additional paid in capital, preferred stock. + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 65 -Paragraph 15 -Subparagraph (g)(2) -URI http://asc.fasb.org/extlink&oid=121322162&loc=SL121327923-165333 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 210 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SX 210.5-02(30)(a)(1)) -URI http://asc.fasb.org/extlink&oid=120391452&loc=d3e13212-122682 + Details
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- Definition Amount of decrease in additional paid in capital (APIC) resulting from direct costs associated with issuing stock. Includes, but is not limited to, legal and accounting fees and direct costs associated with stock issues under a shelf registration. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 505 -SubTopic 10 -Section 50 -Paragraph 2 -URI http://asc.fasb.org/extlink&oid=109259400&loc=d3e21463-112644 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 505 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SX 210.3-04) -URI http://asc.fasb.org/extlink&oid=120397183&loc=d3e187085-122770 + Details
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