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Collaboration arrangements and concentration of credit risk - BMS collaboration - Narrative (Details) $ in Thousands				3 Months Ended		6 Months Ended
	Jun. 24, 2021 USD ($)	Dec. 01, 2020 USD ($) item	Jun. 24, 2020 USD ($)	Jun. 30, 2021 USD ($)	Jun. 30, 2020 USD ($)	Jun. 30, 2021 USD ($) item	Jun. 30, 2020 USD ($)	Dec. 31, 2020 USD ($)
Collaboration arrangements
Number of collaboration targets | item						4
Revenue				$ 463,868	$ 1,535	$ 464,322	$ 1,639
Accounts receivables				$ 2,705		$ 2,705		$ 6,618
Tax rate enacted in the Netherlands				25.00%		25.00%
Tax benefit past share issuance cost				$ 2,977		$ 2,977
CSL Behring collaboration
Collaboration arrangements
Revenue				462,400		462,400
Upfront cash to receive upon the closing of the agreement	$ 450,000		$ 450,000
Other payments received	$ 12,400
Accounts receivables				1,300		1,300		$ 2,100
Regulatory and commercial milestone payments received			$ 1,600,000
License revenues from related party
Collaboration arrangements
Revenue					1,530		1,577
Collaboration revenues from related party
Collaboration arrangements
Revenue					5		62
Collaboration revenues
Collaboration arrangements
Revenue				1,468		$ 1,922
Collaboration revenues | CSL Behring collaboration
Collaboration arrangements
Revenue				$ 400	$ 0		$ 0
BMS arrangement | Bristol Myers Squibb
Collaboration arrangements
Initial research term						4 years
Number of collaboration targets | item		4
Collaboration Agreement, Threshold Number Of Collaboration Targets That Can Be Replaced | item		2
Threshold Number Of New Collaboration Targets In The Field Of Cardiovascular Disease | item		2
License revenue | Bristol Myers Squibb
Collaboration arrangements
Revenue						$ 0
Bristol Myers Squibb | BMS arrangement
Collaboration arrangements
Collaboration Agreement, Threshold Research, Development And Regulatory Milestone Payments Receivable		$ 217,000

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