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Shareholders' equity (Details) - USD ($)
$ / shares in Units, $ in Thousands
2 Months Ended 3 Months Ended 6 Months Ended
Mar. 01, 2021
Apr. 30, 2021
Jun. 30, 2021
Jun. 30, 2021
Dec. 31, 2020
Aggregate offering price     $ 1,865 $ 29,564  
Additional paid-in-capital     1,062,234 1,062,234 $ 1,016,018
Cash consideration paid       46,300  
Sales Agreement with SVB Leerink LLC          
Percentage of gross proceeds 3.00%        
Net proceeds   $ 29,600      
Sales Agreement with SVB Leerink LLC | Direct Incremental Labor          
Adjustments to Additional Paid in Capital, Stock Issued, Issuance Costs     $ 300 $ 1,300  
Sales Agreement with SVB Leerink LLC | Ordinary shares          
Shares issued in connection with offering   921,730      
Share price (in dollars per share)   $ 33.52      
Sales Agreement with SVB Leerink LLC | Maximum          
Aggregate offering price $ 200,000