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Share-based compensation - Summary of share-based compensation expense and unrecognized costs (Details) - 2014 Plan - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2021	Jun. 30, 2020	Jun. 30, 2021	Jun. 30, 2020	Dec. 31, 2020
Share-based compensation
Authorized shares	12,601,471		12,601,471
Increase in authorized shares			4,000,000
Share-based compensation expense	$ 7,021	$ 5,714	$ 12,775	$ 10,054
Unrecognized compensation costs	60,607		$ 60,607
Weighted-average remaining period for recognition (in years)			2 years 7 months 28 days
Research and development expenses
Share-based compensation
Share-based compensation expense	3,286	2,889	$ 5,960	5,271
Selling, general and administrative expense
Share-based compensation
Share-based compensation expense	3,735	2,825	6,815	4,783
Share options
Share-based compensation
Share-based compensation expense	$ 3,350	2,746	$ 6,190	4,954
Outstanding of fully vested share options	3,417,931		3,417,931		2,659,279
Unrecognized compensation costs	$ 34,855		$ 34,855
Weighted-average remaining period for recognition (in years)			2 years 11 months 26 days
Restricted share units ("RSUs")
Share-based compensation
Share-based compensation expense	3,222	2,209	$ 5,782	3,653
Unrecognized compensation costs	24,960		$ 24,960
Weighted-average remaining period for recognition (in years)			2 years 3 months
Performance share units ("PSUs")
Share-based compensation
Share-based compensation expense	449	$ 759	$ 803	$ 1,447
Unrecognized compensation costs	$ 792		$ 792
Weighted-average remaining period for recognition (in years)			6 months 29 days

X

- Definition

Amount of expense for award under share-based payment arrangement. Excludes amount capitalized.

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Amount of cost not yet recognized for nonvested award under share-based payment arrangement.

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