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Basic and diluted earnings per share (Details) - shares	3 Months Ended		6 Months Ended
	Jun. 30, 2021	Jun. 30, 2020	Jun. 30, 2021	Jun. 30, 2020
Basic and diluted earnings per share
Total potential dilutive ordinary shares	3,393,724	11,600,123	3,361,343	11,603,143
BMS Warrants | Bristol Myers Squibb
Basic and diluted earnings per share
Total potential dilutive ordinary shares		8,060,500		8,060,500
Stock options | Previous plan
Basic and diluted earnings per share
Total potential dilutive ordinary shares	2,634,766	2,893,733	2,607,830	2,893,733
Stock options | ESPP
Basic and diluted earnings per share
Total potential dilutive ordinary shares	1,414	254	1,802	254
Non-vested and earned RSUs and PSUs
Basic and diluted earnings per share
Total potential dilutive ordinary shares	757,544	645,636	751,711	645,636

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- Definition

Securities (including those issuable pursuant to contingent stock agreements) that could potentially dilute basic earnings per share (EPS) or earnings per unit (EPU) in the future that were not included in the computation of diluted EPS or EPU because to do so would increase EPS or EPU amounts or decrease loss per share or unit amounts for the period presented.

+ References

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 260
-SubTopic 10
-Section 50
-Paragraph 1
-Subparagraph (c)
-URI http://asc.fasb.org/extlink&oid=6371337&loc=d3e3550-109257

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+ References

No definition available.

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