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CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands | 9 Months Ended
--- | ---
Sep. 30, 2021 | Sep. 30, 2020
Cash flows from operating activities |  |
Net income / (loss) | $ 321,381 | $ (124,325)
Adjustments to reconcile net income / (loss) to net cash generated from / (used in) operating activities: |  |
Depreciation and amortization expense | 5,447 | 8,354
Share-based compensation expense | 18,747 | 16,450
Deferred tax expense | 3,560 |
Changes in fair value of contingent consideration and derivative financial instruments | 416 | (2,531)
Unrealized foreign exchange (gains) / loss, net | (23,242) | 7,758
Other non-cash items, net | (2,862) | (2,082)
Changes in operating assets and liabilities: |  |
Accounts receivable, prepaid expenses, and other current assets and receivables | (1,993) | (1,183)
Accounts payable | 2,003 | (3,724)
Accrued expenses, other liabilities, and operating leases | 11,592 | 3,630
Net cash generated from / (used in) operating activities | 335,049 | (97,653)
Cash flows from investing activities |  |
Acquisition of Corlieve, net of cash acquired | (49,949) |
Purchases of intangible assets |  | (2,314)
Purchases of property, plant, and equipment | (13,885) | (4,475)
Net cash used in investing activities | (63,834) | (6,789)
Cash flows from financing activities |  |
Proceeds from loan increment, net of debt issuance costs | 34,603 |
Proceeds from issuance of ordinary shares | 30,899 |
Share issuance costs from issuance of ordinary shares | (1,334) |
Proceeds from issuance of ordinary shares related to employee stock option and purchase plans | 1,971 | 3,688
Repayment of debt acquired through acquisition of Corlieve | (1,175) |
Net cash generated from financing activities | 64,964 | 3,688
Currency effect on cash, cash equivalents and restricted cash | (2,589) | 2,235
Net increase / (decrease) in cash, cash equivalents and restricted cash | 333,590 | (98,519)
Cash, cash equivalents and restricted cash at beginning of period | 247,680 | 380,726
Cash, cash equivalents and restricted cash at the end of period | 581,270 | 282,207
Cash and cash equivalents | 578,464 | 279,493
Restricted cash related to leasehold and other deposits | 2,806 | 2,714
Total cash, cash equivalents and restricted cash | 581,270 | 282,207
Supplemental cash flow disclosures: |  |
Cash paid for interest | (4,503) | (3,342)
Non-cash increase in accounts payables and accrued expenses and other current liabilities related to purchases of intangible assets and property, plant, and equipment | $ 415 | $ 116

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