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Basic and diluted earnings per share (Details) - shares | 3 Months Ended | 9 Months Ended
--- | --- | ---
Sep. 30, 2021 | Sep. 30, 2020 | Sep. 30, 2021 | Sep. 30, 2020
Basic and diluted earnings per share |  |  |  |
Total potential dilutive ordinary shares | 4,200,111 | 11,705,960 | 3,309,299 | 11,705,960
BMS Warrants | Bristol Myers Squibb |  |  |  |
Basic and diluted earnings per share |  |  |  |
Total potential dilutive ordinary shares |  | 8,071,000 |  | 8,071,000
Stock options | Previous plan |  |  |  |
Basic and diluted earnings per share |  |  |  |
Total potential dilutive ordinary shares | 3,357,412 | 2,960,158 | 2,572,470 | 2,960,158
Stock options | ESPP |  |  |  |
Basic and diluted earnings per share |  |  |  |
Total potential dilutive ordinary shares | 1,219 | 1,997 | 1,219 | 1,997
Non-vested RSUs and PSUs |  |  |  |
Basic and diluted earnings per share |  |  |  |
Total potential dilutive ordinary shares | 841,480 | 672,805 | 735,610 | 672,805

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