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Share-based compensation - Summary of share-based compensation expense and unrecognized costs (Details) - 2014 Plan - USD ($) $ in Thousands		1 Months Ended	3 Months Ended		9 Months Ended
	May 31, 2021	Jun. 30, 2021	Sep. 30, 2021	Sep. 30, 2020	Sep. 30, 2021	Sep. 30, 2020
Share-based compensation
Increase in authorized shares	8,601,471	12,601,471
Share-based compensation expense			$ 5,950	$ 6,363	$ 18,725	$ 16,417
Unrecognized compensation costs			55,198		$ 55,198
Weighted-average remaining period for recognition (in years)					2 years 6 months 25 days
Research and development expenses
Share-based compensation
Share-based compensation expense			3,245	3,906	$ 9,205	9,177
Selling, general and administrative expense
Share-based compensation
Share-based compensation expense			2,705	2,457	9,520	7,240
Share options
Share-based compensation
Share-based compensation expense			2,965	3,994	9,155	8,948
Unrecognized compensation costs			31,952		$ 31,952
Weighted-average remaining period for recognition (in years)					2 years 11 months 4 days
Restricted share units ("RSUs")
Share-based compensation
Share-based compensation expense			2,582	1,525	$ 8,364	5,178
Unrecognized compensation costs			21,887		$ 21,887
Weighted-average remaining period for recognition (in years)					2 years 1 month 28 days
Performance share units ("PSUs")
Share-based compensation
Share-based compensation expense			403	$ 844	$ 1,206	$ 2,291
Unrecognized compensation costs			$ 1,359		$ 1,359
Weighted-average remaining period for recognition (in years)					9 months 3 days

X

- Definition

Amount of expense for award under share-based payment arrangement. Excludes amount capitalized.

+ References

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-Publisher FASB
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Amount of cost not yet recognized for nonvested award under share-based payment arrangement.

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Weighted-average period over which cost not yet recognized is expected to be recognized for award under share-based payment arrangement, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents reported fact of one year, five months, and thirteen days.

+ References

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